Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan
Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan
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DOI：
10.1128/iai.67.8.4295-4297.1999
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发表时间：
1999-08-01
影响因子：
3.1
通讯作者：
van der Poll, T
中科院分区：
文献类型：
--
作者：
Juffermans, NP;Verbon, A;van der Poll, T
结核病患者的白细胞介素8（IL-8）、γ干扰素诱导蛋白10（IP-10）、单核细胞趋化蛋白1（MCP-1）和巨噬细胞炎症蛋白1 β（MIP-1 β）水平升高。IP-10和MCP-1水平在人类免疫缺陷病毒（HIV）血清阳性患者高于HIV血清阴性结核病患者。在体外，脂阿拉伯甘露聚糖诱导IL-8、MCP-1和MIP-1 β，这被抗肿瘤坏死因子抗体部分抑制。
Levels of interleukin 8 (IL-8), gamma interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 beta (MIP-1 beta) were elevated in patients with tuberculosis. IP-10 and MCP-1 levels were higher in human immunodeficiency virus (HIV)-seropositive patients than in HIV-seronegative patients with tuberculosis. Lipoarabinomannan induced IL-8, MCP-1, and MIP-1 beta in vitro, which was partly inhibited by anti-tumor necrosis factor antibody.