Serum levels of leptin, adiponectin and resistin are interrelated and related to total antioxidant capacity, free fatty acids and phospholipids in early neonatal life
Serum levels of leptin, adiponectin and resistin are interrelated and related to total antioxidant capacity, free fatty acids and phospholipids in early neonatal life
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DOI：
10.1016/j.clinbiochem.2011.12.022
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发表时间：
2012-03-01
影响因子：
2.8
通讯作者：
Eroz, Esma
中科院分区：
文献类型：
--
作者：
Ozarda, Yesim;Tuncer, Gul Ozlem;Eroz, Esma
目的：本研究的目的是确定婴儿血清瘦素、脂联素和抵抗素、胰岛素样生长因子-1 (IGF-1)、总抗氧化能力 (TAC)、非酯化脂肪酸 (NEFA) 和磷脂浓度之间的相互关系。设计和方法：进行横断面研究以评估血清瘦素、脂联素、抵抗素、IGF-1、TAC、NEFA 和对出生后4-30天入组的45名母乳喂养婴儿的磷脂进行检测。结果：血清瘦素和脂联素浓度呈正相关。血清抵抗素浓度与血清瘦素和脂联素浓度呈负相关。血清TAC与血清瘦素和脂联素呈正相关，与血清抵抗素浓度呈负相关。血清脂联素浓度与血清NEFA和磷脂浓度呈正相关。血清抵抗素浓度与血清NEFA和磷脂浓度呈负相关。结论：这些数据表明瘦素、脂联素和抵抗素的循环水平是相互关联的，并且它们显然与婴儿的抗氧化系统相互作用。 (C) 2012 年加拿大临床化学家协会。由爱思唯尔公司出版。保留所有权利。
Objectives: The aims of this study were to determine interrelationships between serum leptin, adiponectin and resistin, insulin-like growth factor-1 (IGF-1), total antioxidant capacity (TAC), non-esterified fatty acids (NEFA) and phospholipids concentrations in infants.Design and methods: A cross-sectional study was conducted to assess serum levels of leptin, adiponectin, resistin, IGF-1, TAC, NEFA and phospholipids in 45 breast-fed infants enrolled at 4-30 days after birth.Results: Serum leptin and adiponectin concentrations were positively correlated. Serum resistin concentrations were inversely correlated to serum leptin and adiponectin concentrations. Serum TAC was positively correlated to serum leptin and adiponectin, and inversely to serum resistin concentrations. Serum adiponectin concentrations were positively related to serum NEFA and phospholipid concentrations. Serum resistin concentrations were inversely related to serum NEFA, and phospholipid concentrations.Conclusion: These data show that circulatory levels of leptin, adiponectin and resistin are interrelated and they apparently interact with the anti-oxidant system of infants. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.