Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases.
Interrelation Between Fibroblasts and T Cells in Fibrosing Interstitial Lung Diseases.
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DOI：
10.3389/fimmu.2021.747335
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发表时间：
2021
影响因子：
7.3
通讯作者：
Su J
中科院分区：
文献类型：
--
作者：
Lai Y;Wei X;Ye T;Hang L;Mou L;Su J
间质性肺疾病（ILD）是一组异质性疾病，其特征在于不同程度的炎症和肺纤维化。多种免疫细胞和基质细胞之间的相互作用参与了ILD的发病机制。虽然成纤维细胞通过在活化时分泌细胞外基质和促炎细胞因子而促进ILD的发展，但T细胞是ILD患者肺中的适应性免疫以及炎症和自身免疫组织破坏的主要介质。成纤维细胞在调节T细胞募集、分化和功能中起重要作用，相反，T细胞可以平衡肺中的纤维化后遗症与保护性免疫。对成纤维细胞和T细胞之间相互关系的更精确理解将通过靶向这种相互关系实现更好的未来治疗设计。在这里，我们强调最近的工作成纤维细胞和T细胞之间的相互作用，在ILD的治疗，并考虑这些相互作用的影响，在未来的发展。
Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterized by varying degrees of inflammation and fibrosis of the pulmonary interstitium. The interrelations between multiple immune cells and stromal cells participate in the pathogenesis of ILDs. While fibroblasts contribute to the development of ILDs through secreting extracellular matrix and proinflammatory cytokines upon activation, T cells are major mediators of adaptive immunity, as well as inflammation and autoimmune tissue destruction in the lung of ILDs patients. Fibroblasts play important roles in modulating T cell recruitment, differentiation and function and conversely, T cells can balance fibrotic sequelae with protective immunity in the lung. A more precise understanding of the interrelation between fibroblasts and T cells will enable a better future therapeutic design by targeting this interrelationship. Here we highlight recent work on the interactions between fibroblasts and T cells in ILDs, and consider the implications of these interactions in the future development of therapies for ILDs.
影响因子：
5.8
作者：
Vancheri C;Mastruzzo C;Trovato-Salinaro E;Gili E;Lo Furno D;Pistorio MP;Caruso M;La Rosa C;Crimi C;Failla M;Crimi N
通讯作者：
Crimi N