The associations of interstitial lung abnormalities with cancer diagnoses and mortality.
The associations of interstitial lung abnormalities with cancer diagnoses and mortality.
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DOI：
10.1183/13993003.02154-2019
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Gudmundsson G
中科院分区：
文献类型：
--
作者：
Axelsson GT;Putman RK;Aspelund T;Gudmundsson EF;Hida T;Araki T;Nishino M;Hatabu H;Gudnason V;Hunninghake GM;Gudmundsson G
在特发性肺纤维化患者中，肺癌发病率的增加是众所周知的。目前尚不清楚肺间质异常，即肺早期纤维化改变，是否是普通人群肺癌的危险因素。这项研究的目的是评估间质性肺异常是否与肺癌和其他癌症的诊断和死亡有关。研究使用了AGES-雷克雅未克研究的数据，该研究对5764名冰岛老年人进行了队列调查。结果数据从电子病历中确定。采用Gray‘s检验、Cox比例风险模型和比例分布风险模型分析肺间质病变与肺癌诊断、肺癌死亡率以及所有癌症的诊断和死亡率之间的关系。有肺间质异常的参与者的肺癌诊断累积发病率(P<；0.001)和肺癌死亡率(P<；0.001)高于其他参与者。在校正的COX模型中，肺间质异常与肺癌诊断风险(HR=2.77)和肺癌死亡率(HR=2.89)增加相关。在包括肺癌的模型中发现间质肺异常与所有癌症的关联，但在排除肺癌的模型中没有发现。有肺间质异常的人患肺癌和肺癌死亡率的风险增加，但不会增加其他癌症的风险。这意味着肺纤维化和肿瘤性肺部疾病之间的联系从肺纤维化的早期阶段就存在，并表明间质肺异常是肺癌筛查工作中的一个危险因素。在一般人群队列中，间质性肺异常与肺癌诊断风险和肺癌死亡率的增加有关。除肺癌外，其他癌症与间质性肺异常无关。
An increased incidence of lung cancer is well-known among patients with idiopathic pulmonary fibrosis. It is unknown whether interstitial lung abnormalities, early fibrotic changes of the lung, are a risk factor for lung cancer in the general population. The study’s objective was to assess whether interstitial lung abnormalities were associated with diagnoses of, and mortality from, lung cancer and other cancers. Data from the AGES-Reykjavik study, a cohort of 5,764 elderly Icelanders, were used. Outcome data were ascertained from electronic medical records. Gray’s tests, Cox proportional hazards models and proportional subdistribution hazards models were used to analyse associations of interstitial lung abnormalities with lung cancer diagnoses and lung cancer mortality as well as diagnoses and mortality from all cancers. Participants with interstitial lung abnormalities had greater cumulative incidence of lung cancer diagnoses (p < 0.001) and lung cancer mortality (p < 0.001) than others. Interstitial lung abnormalities were associated with an increased hazard of lung cancer diagnosis (HR = 2.77) and lung cancer mortality (HR = 2.89) in adjusted Cox models. Associations of interstitial lung abnormalities with all cancers were found in models including lung cancers but not in models excluding lung cancers. People with interstitial lung abnormalities are at increased risk of lung cancer and lung cancer mortality, but not of other cancers. This implies that an association between fibrotic and neoplastic lung diseases of the lung exists from the early stages of lung fibrosis and suggests interstitial lung abnormalities as a risk factor in lung cancer screening efforts. Interstitial lung abnormalities are associated with an increased hazard of lung cancer diagnosis and mortality from lung cancer in a general population cohort. Cancers other than lung cancer were not associated with interstitial lung abnormalities.
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DOI：
10.1056/nejmoa1007285
发表时间：
2011-03-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Washko GR;Hunninghake GM;Fernandez IE;Nishino M;Okajima Y;Yamashiro T;Ross JC;Estépar RS;Lynch DA;Brehm JM;Andriole KP;Diaz AA;Khorasani R;D'Aco K;Sciurba FC;Silverman EK;Hatabu H;Rosas IO;COPDGene Investigators
通讯作者：
COPDGene Investigators
特发性肺纤维化和癌症：它们看起来真的相似吗？
影响因子：
9.3
作者：
Vancheri C
通讯作者：
Vancheri C
DOI：
10.1056/nejmoa1216076
发表时间：
2013-06-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hunninghake GM;Hatabu H;Okajima Y;Gao W;Dupuis J;Latourelle JC;Nishino M;Araki T;Zazueta OE;Kurugol S;Ross JC;San José Estépar R;Murphy E;Steele MP;Loyd JE;Schwarz MI;Fingerlin TE;Rosas IO;Washko GR;O'Connor GT;Schwartz DA
通讯作者：
Schwartz DA
DOI：
10.1164/rccm.201903-0511oc
发表时间：
2019-12-01
影响因子：
24.7
作者：
Hobbs, Brian D.;Putman, Rachel K.;Viviano, Lisa
通讯作者：
Viviano, Lisa
影响因子：
4.3
作者：
Le Jeune, Ivan;Gribbin, Jonathan;Hubbard, Richard
通讯作者：
Hubbard, Richard