Alcohol Consumption and Lung Cancer Risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study
Alcohol Consumption and Lung Cancer Risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study
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DOI：
10.1093/aje/kwp332
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发表时间：
2010-01-01
影响因子：
5
通讯作者：
Landi, Maria Teresa
中科院分区：
文献类型：
--
作者：
Bagnardi, Vincenzo;Randi, Giorgia;Landi, Maria Teresa
作者在肺癌病因学(EAGLE)研究中调查了饮酒与肺癌风险在环境和遗传学中的关系，这是一项基于人群的病例对照研究。在2002至2005年间，从意大利伦巴第区的13家医院招募了2100名原发性肺癌患者，并在性别、居住地和年龄方面与随机选择的2120名对照组进行了频率匹配。对1,855名患者和2,065名对照组的成年期间饮酒情况进行了评估。收集了有关终生吸烟、饮食、教育和人体测量的数据。使用非条件Logistic回归计算调整后的优势比和平均每日酒精摄入量类别的95%可信区间。总体而言，不饮酒者(优势比=1.42，95%可信区间：1.03，2.01)和非常酗酒者(>；=60克/天；优势比=1.44，95%可信区间：1.01，2.07)的风险明显高于饮酒量很少的人(0.1-4.9克/天)。吸烟行为改变了酒精效应，在从不吸烟的人中没有观察到额外的风险。综上所述，在这项研究中，大量饮酒是吸烟者患肺癌的危险因素。虽然不能排除吸烟造成的残留混淆，但这一发现可能反映了酒精和吸烟之间的相互作用，强调了预防措施的必要性。
The authors investigated the relation between alcohol consumption and lung cancer risk in the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study, a population-based case-control study. Between 2002 and 2005, 2,100 patients with primary lung cancer were recruited from 13 hospitals within the Lombardy region of Italy and were frequency-matched on sex, area of residence, and age to 2,120 randomly selected controls. Alcohol consumption during adulthood was assessed in 1,855 cases and 2,065 controls. Data on lifetime tobacco smoking, diet, education, and anthropometric measures were collected. Adjusted odds ratios and 95% confidence intervals for categories of mean daily ethanol intake were calculated using unconditional logistic regression. Overall, both nondrinkers (odds ratio = 1.42, 95% confidence interval: 1.03, 2.01) and very heavy drinkers (>= 60 g/day; odds ratio = 1.44, 95% confidence interval: 1.01, 2.07) were at significantly greater risk than very light drinkers (0.1-4.9 g/day). The alcohol effect was modified by smoking behavior, with no excess risk being observed in never smokers. In summary, heavy alcohol consumption was a risk factor for lung cancer among smokers in this study. Although residual confounding by tobacco smoking cannot be ruled out, this finding may reflect interplay between alcohol and smoking, emphasizing the need for preventive measures.