Maternal concentrations of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) and duration of breastfeeding
Maternal concentrations of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) and duration of breastfeeding
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DOI：
10.5271/sjweh.2908
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发表时间：
2010-09-01
影响因子：
6.3
通讯作者：
Olsen, Jorn
中科院分区：
文献类型：
--
作者：
Fei, Chunyuan;McLaughlin, Joseph K.;Olsen, Jorn
目的 全氟辛酸 (PFOA) 与小鼠泌乳受损有关。我们检查了母亲全氟辛烷磺酸（PFOS）和PFOA浓度是否与女性母乳喂养时间相关。方法我们从丹麦国家出生队列（1996-2002）中随机抽取1400名孕妇，采用高效液相色谱/串联质谱法测量妊娠早期PFOS和PFOA浓度。在孩子出生后 6 个月和 18 个月左右的电话访谈中，收集了两次有关母乳喂养和纯母乳喂养持续时间的自我报告数据。 结果 经产妇女中，母乳喂养持续时间随着妊娠 PFOS 和 PFOA 浓度的增加而缩短，对于这些妇女来说，6 月龄前断奶的调整比值比 (OR) 为每增加 10 ng/ml 1.20（95% CI 1.06-1.37）。 PFOS 浓度每增加 1 ng/ml，PFOA 浓度增加 1.23 (95% CI 1.13-1.33)。对于初产妇女没有发现一致的关联。结论这些研究结果表明，PFOA 和 PFOS 可能会降低泌乳能力，但同样可以反映相反的因果关系，因为在初产妇女中没有发现关联。
Objective Perfluorooctanoate (PFOA) has been associated with impaired lactation in mice. We examined whether maternal perfluorooctanesulfonate (PFOS) and PFOA concentrations correlated with duration of breastfeeding among women.Methods We randomly selected 1400 pregnant women from the Danish national birth cohort (1996-2002) and measured PFOS and PFOA concentrations in early pregnancy by using high performance liquid chromatography/tandem mass spectrometry. Self-reported data on the duration of any and exclusive breastfeeding were collected twice during telephone interviews around 6 and 18 months after the birth of the child.Results The duration of breastfeeding decreased with increasing concentrations of pregnancy PFOS and PFOA among multiparous women, for whom the adjusted odds ratios (OR) for weaning before 6 months of age were 1.20(95% CI 1.06-1.37) per 10 ng/ml increase in PFOS concentrations and 1.23 (95% CI 1.13-1.33) per 1 ng/ml increase in PFOA concentrations. No consistent association was found for primiparous women.Conclusions These findings suggest that PFOA and PFOS may reduce the ability to lactate, but could equally reflect reverse causation since no association was seen in primiparous women.