Effect of polymyxin B-immobilized fibre on various mediators in patients with hypothermic sepsis
Effect of polymyxin B-immobilized fibre on various mediators in patients with hypothermic sepsis
复制标题
多粘菌素B固定纤维对低温脓毒症患者多种介质的影响
DOI：
10.3109/tcic.12.5-6.223.228
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
H. Koide
中科院分区：
文献类型：
--
作者：
Tsukasa Nakamura;C. Ushiyama;Yoshimasa Suzuki;H. Shoji;S. Osada;N. Shimada;H. Koide
目的：我们比较多粘菌素 B 固定纤维（PMX-F）治疗与常规治疗对低温脓毒症患者血浆中各种介质浓度的影响。设计和受试者：本研究包括 120 名发热患者和 20 名低温脓毒症患者以及 40 名健康对照。通过酶免疫测定法测量血栓调节蛋白（TM）和冯维勒布兰德因子（vWF）的血浆水平。通过酶联免疫吸附测定法测量促红细胞生成素（EPO）和白细胞介素（IL）-6的血浆水平。低温脓毒症患者分为两个治疗组：PMX-F治疗组（A组，n=10）和常规治疗组（B组，n=10）。结果：低温脓毒症患者血浆内毒素、TM、vWF、IL-6和EPO浓度显着高于发热性脓毒症患者（p<0.05或p<0.001）。 A 组的存活率为 60%，B 组的存活率为 10%。PMX-F 显着降低了 A 组的这些浓度（p<0.01）...
Objective: We compared the effects of polymyxin B-immobilized fibre (PMX-F) therapy and conventional treatment on plasma concentrations of various mediators in patients with hypothermic sepsis. Design and subjects: One-hundred and twenty febrile and 20 hypothermic sepsis patients and 40 healthy controls were included in this study. Plasma levels of thrombomudulin (TM) and von Willebrand factor (vWF) were measured by enzyme immunoassay. Plasma levels of erythropoietin (EPO) and interleukin (IL)-6 were measured by enzyme-linked immunosorbent assay. Hypothermic sepsis patients were divided into two treatment groups: PMX-F treatment group (group A, n=10) and conventional treatment group (group B, n=10). Results: Plasma endotoxin, TM, vWF, IL-6 and EPO concentrations were significantly higher in hypothermic sepsis patients than in febrile sepsis patients (p<0.05 or p<0.001). The survival rate was 60% in group A and 10% in group B. PMX-F reduced these concentrations significantly in group A (p<0.01) wh...
影响因子：
8.8
作者：
BARRIERE, SL;LOWRY, SF
通讯作者：
LOWRY, SF
发烧的神经学基础。
DOI：
10.1056/nejm199406303302609
发表时间：
1994
期刊：
The New England journal of medicine
影响因子：
--
作者：
Saper,CB;Breder,CD
通讯作者：
Breder,CD