The bioactive amide alkaloids from the stems of Piper nigrum.
The bioactive amide alkaloids from the stems of Piper nigrum.
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DOI：
10.1016/j.foodchem.2022.134736
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发表时间：
2022-10
期刊：
影响因子：
8.8
通讯作者：
Jie Xu;Yu-Cheng Wei;Qingyu Liu;Xingxing Liu;Chengjing Zhu;Yijun Tu;Jiachuan Lei;Jianqing Yu
中科院分区：
文献类型：
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作者：
Jie Xu;Yu-Cheng Wei;Qingyu Liu;Xingxing Liu;Chengjing Zhu;Yijun Tu;Jiachuan Lei;Jianqing Yu
胡椒是一种重要的芳香植物，其果实（黑胡椒和白色胡椒）常用作食品添加剂和香料。然而，它的茎被作为废物处理。本研究对茎中的生物活性生物碱进行了全面的研究，共分离得到8个新的二聚酰胺类生物碱和8个已知化合物。所得化合物均表现出良好的抗炎活性。此外，二聚酰胺生物碱增强了紫杉醇对宫颈癌细胞的抗癌作用。这些结果表明，P.黑色素可作为生物活性生物碱的可持续来源，在食品和保健领域得到开发利用。
Piper nigrumis an important aromatic plant, and its fruits (black and white pepper) are commonly used as food additives and spices. However, its stems were disposed as wastes. This research comprehensively investigated bioactive alkaloids of the stems, eight new dimeric amide alkaloids and eight known compounds were obtained. All obtained compounds showed excellent anti-inflammatory activity. Additionally, the dimeric amide alkaloids enhanced the anticancer effect of paclitaxel against cervical cancer cells. These results demonstrate that the stems ofP. nigrumcould be the sustainable source of bioactive alkaloids for development and utilization in the food and health fields.