Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes.
Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes.
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DOI：
10.4049/jimmunol.1000812
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发表时间：
2010-12-01
期刊：
影响因子：
--
通讯作者：
Selin LK
中科院分区：
文献类型：
--
作者：
Clute SC;Naumov YN;Watkin LB;Aslan N;Sullivan JL;Thorley-Lawson DA;Luzuriaga K;Welsh RM;Puzone R;Celada F;Selin LK
Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a process known as heterologous immunity. Because a challenge virus epitope may react with only a subset of the T cell repertoire in a cross-reactive epitope-specific memory pool, the vigorous cross-reactive response may be narrowly focused, or oligoclonal. We show here, by examining human T cell cross-reactivity between the HLA-A2-restricted influenza A virus-encoded M158-66 epitope (GILGFVFTL) and the dissimilar Epstein-Barr virus-encoded BMLF1280-288 epitope (GLCTLVAML), that under some conditions heterologous immunity can lead to a significant broadening rather than a narrowing of the T cell receptor repertoire. We suggest that dissimilar cross-reactive epitopes might generate a broad rather than narrow T cell repertoire if there is a lack of dominant high affinity clones, and this hypothesis is supported by computer simulation.
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影响因子：
15.3
作者：
Cibotti, Ricardo;Cabaniols, Jean-Pierre;Pannetier, Christophe;Delarbre, Christiane;Vergnon, Isabelle;Kanellopoulos, Jean M.;Kourilsky, Philippe
通讯作者：
Kourilsky, Philippe
DOI：
10.1084/jem.190.9.1319
发表时间：
1999-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Haanen JB;Wolkers MC;Kruisbeek AM;Schumacher TN
通讯作者：
Schumacher TN
影响因子：
4.4
作者：
Lawson, TM;Man, S;Borysiewicz, LK
通讯作者：
Borysiewicz, LK
影响因子：
5.5
作者：
Cheng, Yiming;Ghersi, Dario;Celada, Franco
通讯作者：
Celada, Franco
影响因子：
5.5
作者：
Kohler, B;Puzone, R;Celada, F
通讯作者：
Celada, F