Andrastins A similar to C, new protein farnesyltransferase inhibitors produced by Penicillium sp FO-3929 .1. Producing strain, fermentation isolation, and biological activities
Andrastins A similar to C, new protein farnesyltransferase inhibitors produced by Penicillium sp FO-3929 .1. Producing strain, fermentation isolation, and biological activities
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DOI：
10.7164/antibiotics.49.414
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发表时间：
1996-05-01
影响因子：
3.3
通讯作者：
Yamamura, S
中科院分区：
文献类型：
--
作者：
Omura, S;Inokoshi, J;Yamamura, S
在青霉FO-3929的培养液中发现了新的蛋白质法尼基转移酶抑制剂，andrastins A类似于C。从发酵液上清中提取Andrastins，通过硅胶层析、ODS层析和HPLC进行纯化。andrastins A、B和C对蛋白法尼基转移酶的IC 50分别为24.9、47.1和13.3 μ M。
New protein farnesyltransferase inhibitors, andrastins A similar to C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 mu M, respectively.