THE HUMAN C-ROS GENE (ROS) IS LOCATED AT CHROMOSOME REGION 6Q16-]6Q22
THE HUMAN C-ROS GENE (ROS) IS LOCATED AT CHROMOSOME REGION 6Q16-]6Q22
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DOI：
10.1073/pnas.83.17.6568
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发表时间：
1986-09-01
影响因子：
11.1
通讯作者：
CROCE, CM
中科院分区：
文献类型：
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作者：
NAGARAJAN, L;LOUIE, E;CROCE, CM
禽肉瘤病毒UR2的转化基因v-ros的人类同源基因c-ros已从人类基因组文库中分离出来。来自人c-ros基因组克隆的单拷贝片段已被用于将人c-ros同源基因(ROS)定位到人类染色体6q16.fwdarw区域。6q22进行体细胞杂交和染色体原位杂交。因此，c-ros基因加入了c-myb癌基因，c-myb癌基因位于人类6号染色体长臂上c-ros基因的远端，作为参与染色体6q缺失和重排的候选基因，在各种恶性肿瘤中可见。
The human homolog, c-ros, of the transforming gene, v-ros, of the avian sarcoma virus, UR2, has been isolated from a human genomic library. A single-copy fragment from the human c-ros genomic clone has been used to map the human c-ros homolog (ROS) to human chromosome region 6q16 .fwdarw. 6q22 by somatic cell hybrid analysis and chromosomal in situ hybridization. Thus, the c-ros gene joins the c-myb oncogene, which is distal to the c-ros gene on the long arm of human chromosome 6, as a candidate for involvement in chromosome 6q deletions and rearrangements seen in various malignancies.