Catalytic Nucleophilic Fluorination of Secondary and Tertiary Propargylic Electrophiles with a Copper-N-Heterocyclic Carbene Complex
Catalytic Nucleophilic Fluorination of Secondary and Tertiary Propargylic Electrophiles with a Copper-N-Heterocyclic Carbene Complex
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铜-N-杂环卡宾配合物催化二级和三级炔丙基亲电试剂的亲核氟化
DOI：
10.1002/ange.201506882
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发表时间：
2015
影响因子：
--
通讯作者：
Cheng L
中科院分区：
文献类型：
--
作者：
Cheng L
报道了一种炔丙基亲电试剂亲核加成的催化方法。我们的协议涉及使用的Cu（NHC）配合物作为催化剂，是适合于制备仲和叔炔丙基氟，而不形成异构体的氟代联烯。初步的机理研究表明，通过乙炔铜和阳离子物种的参与，crosslinking收益。
A catalytic method for the nucleophilic fluorination of propargylic electrophiles is described. Our protocol involves the use of a Cu(NHC) complex as the catalyst and is suitable for the preparation of secondary and tertiary propargylic fluorides without the formation of isomeric fluoroallenes. Preliminary mechanistic investigations suggest that fluorination proceeds via copper acetylides and that cationic species are involved.