Anterograde transport through the Golgi complex: do Golgi tubules hold the key?
Anterograde transport through the Golgi complex: do Golgi tubules hold the key?
复制标题
通过高尔基复合体的顺行运输：高尔基小管是关键吗？
DOI：
10.1016/s0962-8924(00)89046-7
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发表时间：
1995
影响因子：
19
通讯作者：
P. Weidman
中科院分区：
文献类型：
--
作者：
P. Weidman
生化研究表明，顺行蛋白通过高尔基复合体的运输是由涂有共生膜的小泡介导的，这些小泡从一个隔室发芽，然后转移到下一个隔室，并与之融合。然而，最近的遗传学研究表明，共藻体突变阻止了酵母的逆行运输，但不能阻止顺行运输，这让人对共生胞囊泡在顺行运输中的作用提出了质疑。佩吉·魏德曼提出，如果顺行转运是通过高尔基小管的瞬时融合发生的，如果共生者在小管和囊泡动力学中具有相关但可分离的功能，则可以解释这些发现。
Biochemical studies have suggested that anterograde protein transport through the Golgi complex is mediated by coatomer-coated vesicles that bud from one compartment and then transfer to, and fuse with, the next. However, recent genetic studies have shown that coatomer mutations block retrograde, but not anterograde, transport in yeast, calling into question the role of coatomer vesicles in anterograde transport. Peggy Weidman proposes that these findings might be explained if anterograde transport occurs by transient fusion of Golgi tubules and if coatomers have related, but separable, functions in tubule and vesicle dynamics