ROLE OF SHEAR RATE AND PLATELETS IN PROMOTING FIBRIN FORMATION ON RABBIT SUBENDOTHELIUM - STUDIES UTILIZING PATIENTS WITH QUANTITATIVE AND QUALITATIVE PLATELET DEFECTS
ROLE OF SHEAR RATE AND PLATELETS IN PROMOTING FIBRIN FORMATION ON RABBIT SUBENDOTHELIUM - STUDIES UTILIZING PATIENTS WITH QUANTITATIVE AND QUALITATIVE PLATELET DEFECTS
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DOI：
10.1172/jci112663
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发表时间：
1986-10-01
影响因子：
15.9
通讯作者：
BAUMGARTNER, HR
中科院分区：
文献类型：
--
作者：
WEISS, HJ;TURITTO, VT;BAUMGARTNER, HR
暴露于非抗凝人血的兔主动脉段内皮下血小板沉积随着壁剪切速率的增加而逐渐增加（50-2,600 s-1），而纤维蛋白沉积则减少。对正常受试者和血小板紊乱患者的研究表明，在使用的条件下，血小板对于中等剪切速率（650 s-1）而非低剪切速率（50 s-1）的纤维蛋白沉积是必需的。斯科特综合征患者的血小板结合因子Xa和活性因子IX和II的能力降低，纤维蛋白沉积明显减少。在糖蛋白iib - iiia缺乏的情况下，纤维蛋白沉积正常（或有所增加），而在糖蛋白Ib缺乏的情况下，纤维蛋白与血小板的关联减少，但与内皮下无关。研究结果表明，血小板可能通过凝血蛋白的表面定位，以动脉剪切速率促进纤维蛋白在内皮下层的沉积，并提示针对血小板凝血特性的药物可能具有抗血栓作用。
The deposition of platelets on subendothelium of rabbit aortic segments exposed to non-anticoagulant human blood increased progressively with increasing wall shear rates (50-2,600 s-1), whereas fibrin deposition decreased. Studies in normal subjects and patients with platelet disorders suggested that, under the conditions used, platelets were essential for fibrin deposition at intermediate (650 s-1) but not low (50 s-1) shear rates. Fibrin deposition was markedly diminished in a patient with Scott syndrome whose platelets have a diminished capacity to bind Factor Xa and active Factors IX and II. In glycoprotein IIb-IIIa-deficiency, fibrin deposition was normal (or somewhat increased), whereas in glycoprotein Ib deficiency the association of fibrin with platelets, but not subendothelium, was decreased. The findings indicate that platelets, perhaps through surface localization of coagulation proteins, promote fibrin deposition on subendothelium at arterial shear rates and suggest that agents directed against platelet coagulant properties could be antithrombotic.