Significance of Increased Phosphatase Activity of Bone at the Site of Osteoplastic Metastases Secondary to Carcinoma of the Prostate Gland
Significance of Increased Phosphatase Activity of Bone at the Site of Osteoplastic Metastases Secondary to Carcinoma of the Prostate Gland
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继发于前列腺癌的骨形成性转移部位骨磷酸酶活性增加的意义
DOI：
10.1158/ajc.1936.485a
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发表时间：
1936
影响因子：
0.3
通讯作者：
A. Gutman
中科院分区：
文献类型：
--
作者：
E. Gutman;E. Sproul;A. Gutman
最近对癌症患者血清磷酸酶活性的测定（1,2,3）表明，在广泛的骨成形性转移病例中获得的值通常显著高于与溶骨性转移相关的值。例如，在Gutman， Tyson和Gutman(1)报道的系列研究中，10例骨成骨转移患者中有6例血清磷酸酶活性超过10 Bodansky单位/ 100cc，而19例溶骨转移患者中只有3例。在2例非常广泛的骨成骨病变患者中，每100毫升血清的Bodansky值超过100，而正常最大值为4.0。
Recent determinations of serum phosphatase activity in patients with cancer (1, 2, 3) suggest that values obtained in cases with widespread osteoplastic metastases are, in general, significantly higher than those found in association with osteolytic metastases. In the series reported by Gutman, Tyson and Gutman (1), for example, the serum phosphatase activity exceeded 10 Bodansky units per 100 c.c. in 6 of 10 cases with osteoplastic metastases but in only 3 of 19 patients with osteolytic metastases. In 2 patients with very extensive osteoplastic skeletal lesions, values exceeding 100 Bodansky units per 100 c.c. of serum were obtained, as contrasted with the normal maximum of 4.0 Bodansky units.
It has been assumed (1, 3) that the rise in phosphatase activity of the serum in such cases is the result of increased elaboration of phosphatase, which is subsequently released into the circulating fluids. Direct evidence in support of this assumption is afforded by the present investigation, which disclosed strikingly increased phosphatase activity of bone at the site of osteoplastic skeletal metastases in a patient with carcinoma of the prostate gland.