Y Not a Dead End: Epistatic Interactions Between Y-Linked Regulatory Polymorphisms and Genetic Background Affect Global Gene Expression in Drosophila melanogaster
Y Not a Dead End: Epistatic Interactions Between Y-Linked Regulatory Polymorphisms and Genetic Background Affect Global Gene Expression in Drosophila melanogaster
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DOI：
10.1534/genetics.110.118109
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发表时间：
2010-09-01
期刊：
影响因子：
3.3
通讯作者：
Lemos, Bernardo
中科院分区：
文献类型：
--
作者：
Jiang, Pan-Pan;Hartl, Daniel L.;Lemos, Bernardo
在大多数物种中，Y染色体不经过减数分裂重组从父亲遗传给儿子，携带的基因相对较少。这与进化理论的预测相一致，即非重组染色体缺乏变异并迅速退化。然而，最近的研究表明，Y染色体在基因调控中发挥着动态作用，这一发现对精子发生和男性健康具有重要意义。我们研究了来自两个种群的果蝇的Y染色体，这些Y染色体先前已被证明对精子发生的热耐受性有重大影响。我们发现，这些Y染色体差异修饰数百个常染色体和X连锁基因的表达。显示Y连锁调节变异（YRV）的基因也显示与免疫应答和信息素检测的关联。事实上，位于X染色体的常染色质-异染色质边界附近的基因似乎对Y连锁变异特别敏感，包括大量的气味结合基因。此外，数据显示Y染色体与常染色体和X染色体的遗传背景之间存在显著的调节相互作用。总而言之，我们的研究结果支持了这样的观点：群体间Y连锁调节多态性可以差异调节许多对男性健康重要的基因的表达，并且它们还指出Y染色体和遗传背景之间复杂的相互作用影响了全球基因表达。
The Y chromosome, inherited without meiotic recombination from father to son, carries relatively few genes in most species. This is consistent with predictions from evolutionary theory that nonrecombining chromosomes lack variation and degenerate rapidly. However, recent work has suggested a dynamic role for the Y chromosome in gene regulation, a finding with important implications for spermatogenesis and male fitness. We studied Y chromosomes from two populations of Drosophila melanogaster that had previously been shown to have major effects on the thermal tolerance of spermatogenesis. We show that these Y chromosomes differentially modify the expression of hundreds of autosomal and X-linked genes. Genes showing Y-linked regulatory variation (YRV) also show an association with immune response and pheromone detection. Indeed, genes located proximal to the euchromatin-heterochromatin boundary of the X chromosome appear particularly responsive to Y-linked variation, including a substantial number of odorant-binding genes. Furthermore, the data show significant regulatory interactions between the Y chromosome and the genetic background of autosomes and X chromosome. Altogether, our findings support the view that interpopulation, Y-linked regulatory polymorphisms can differentially modulate the expression of many genes important to male fitness, and they also point to complex interactions between the Y chromosome and genetic background affecting global gene expression.