Is Runx a linchpin for developmental signaling in metazoans?
Is Runx a linchpin for developmental signaling in metazoans?
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DOI：
10.1002/jcb.22143
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发表时间：
2009-05-15
影响因子：
4
通讯作者：
Coffman, James A.
中科院分区：
文献类型：
--
作者：
Coffman, James A.
Runt 结构域 (Runx) 是一个 128 个氨基酸的序列基序，定义了序列特异性 DNA 结合蛋白的后生动物家族，该家族似乎起源于协调动物多细胞发育的细胞间信号系统。在已研究的模型生物（果蝇、小鼠、海胆和线虫）中，Runx 基因对于正常发育至关重要，而在人类中，它们与多种癌症存在因果关系，表现出致癌和肿瘤抑制特性。在发育过程中，Runx 蛋白支持细胞增殖和分化，并在转录激活和抑制中发挥作用。因此，Runx 功能是上下文相关的，上下文由顺式调控序列结构在遗传上提供，而表观遗传则由发育提供。这种上下文依赖性使得很难对正常和致癌发育中的 Runx 功能进行简化概括。然而，越来越多的文献将 Runx 功能与动物的每个主要细胞间信号系统联系起来，表明 Runx 转录因子的一般功能可能是增强和控制基因组对发育信号的反应。
The Runt domain (Runx) is a 128 amino acid sequence motif that defines a metazoan family of sequence-specific DNA binding proteins, which appears to have originated in concert with the intercellular signaling systems that coordinate multicellular development in animals. In the model organisms where they have been studied (fruit fly, mouse, sea urchin, and nematode) Runx genes are essential for normal development, and in humans they are causally associated with a variety of cancers, manifesting both oncogenic and tumor suppressive attributes. During development Runx proteins support both cell proliferation and differentiation, and function in both transcriptional activation and repression. Runx function is thus context-dependent, with the context provided genetically by cis-regulatory sequence architecture and epigenetically by development. This context dependency makes it difficult to formulate reductionistic generalizations concerning Runx function in normal and carcinogenic development. However, a growing body of literature links Runx function to each of the major intercellular signaling systems in animals, suggesting that the general function of Runx transcription factors may be to potentiate and govern genomic responsiveness to developmental signaling.
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影响因子：
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作者：
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DOI：
10.1073/pnas.0800970105
发表时间：
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影响因子：
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评估吗啉代反义靶向海胆 Runx 基因产生的发育表型。
影响因子：
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作者：
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