Arterial stiffness, cognitive decline, and risk of dementia - The Rotterdam study
Arterial stiffness, cognitive decline, and risk of dementia - The Rotterdam study
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DOI：
10.1161/01.str.0000257998.33768.87
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发表时间：
2007-03-01
期刊：
影响因子：
8.3
通讯作者：
Breteler, Monique M. B.
中科院分区：
文献类型：
--
作者：
Poels, Marielle M. F.;van Oijen, Marieke;Breteler, Monique M. B.
背景和目的-动脉僵硬度与心肌梗死和卒中风险增加相关，与经典的血管危险因素无关。血管因素和中风与认知功能和痴呆有关。我们研究了动脉硬化是否与认知功能和dementions.Methods独立相关-本研究是基于鹿特丹研究，前瞻性人群为基础的队列研究自1990年以来正在进行。在第三次检查期间（1997 - 1999年），通过评估脉搏波速度和颈动脉扩张性来测量动脉硬度。在第三次和第四次检查（2002 - 2004年）期间，采用神经心理学成套测验评估认知功能。我们使用线性和逻辑回归来估计动脉硬度与认知功能和认知下降的关系。从第三次检查到2005年1月1日，我们确定了156例痴呆症病例。考克斯比例风险模型被用来估计之间的关联动脉僵硬度和老年痴呆症的风险。结果-调整后的心血管危险因素，我们发现一个关联的脉搏波速度增加与较差的性能上的Stroop测试（调整后的β系数[95%置信区间]为1.13 [0.26 - 1.99]/脉搏波速度的标准差增加），但与其他认知测试的表现无关。动脉硬化和认知能力下降或痴呆风险的措施之间没有发现关联调整后cardiovascular factors.Conclusions -我们没有确定动脉硬化作为一个独立的认知能力下降或痴呆风险的危险因素。
Background and Purpose - Arterial stiffness is associated with an increased risk of myocardial infarction and stroke, independent of classical vascular risk factors. Vascular factors and stroke are associated with cognitive function and dementia. We examined whether arterial stiffness was independently associated with cognitive function and dementia.Methods - The present study was based on the Rotterdam Study, a prospective population-based cohort study ongoing since 1990. During the third examination ( 1997 - 1999) arterial stiffness was measured by assessment of pulse wave velocity and carotid distensibility. Cognitive function was assessed during the third and fourth examination ( 2002 - 2004) with a neuropsychological test battery. We used linear and logistic regression to estimate the association of arterial stiffness with cognitive function and cognitive decline. From the third examination until January 1, 2005, we identified 156 incident dementia cases. Cox proportional hazard models were used to estimate the association between arterial stiffness and the risk of dementia.Results - After adjustment for cardiovascular risk factors we found an association of increased pulse wave velocity with poorer performance on the Stroop test ( adjusted beta-coefficient [95% confidence interval] 1.13 [0.26 to 1.99] per standard deviation increase in pulse wave velocity) but not with performance on other cognitive tests. No associations were found between measures of arterial stiffness and cognitive decline or risk of dementia after adjustment for cardiovascular factors.Conclusions - We did not identify arterial stiffness as an independent risk factor of cognitive decline or risk of dementia.