Liver cancer stem cells.
Liver cancer stem cells.
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DOI：
10.4061/2011/486954
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发表时间：
2011
影响因子：
1.8
通讯作者：
He AR
中科院分区：
文献类型：
--
作者：
Mikhail S;He AR
肝细胞癌是成人肝脏最常见的原发性恶性肿瘤。它也是全球第五大常见的实体癌，也是癌症相关死亡的第三大原因。最近的研究支持肝癌是一种成体干细胞疾病。从实验性肝癌发生的模型来看，可能至少有三种不同的细胞系具有对肿瘤转化敏感的祖细胞特性。识别每种肝细胞类型的特异性细胞表面标志物，生产相应的单克隆抗体和细胞分选技术一起彻底改变了正常干细胞的特征。在肝癌发生过程中，对干细胞增殖和分化重要的多种信号传导途径被失调。目前正在制定识别和表征肝癌干细胞的策略。以肝癌干细胞为靶点可能为肝癌的治疗带来希望。
Hepatocellular carcinoma is the most common primary malignancy of the liver in adults. It is also the fifth most common solid cancer worldwide and the third leading cause of cancer-related death. Recent research supports that liver cancer is a disease of adult stem cells. From the models of experimental hepatocarcinogenesis, there may be at least three distinct cell lineages with progenitor properties susceptible to neoplastic transformation. Identification of specific cell surface markers for each of the liver cell types, production of corresponding monoclonal antibodies and cell sorting techniques have together revolutionized the characteristics of normal stem cells. In hepatocarcinogenesis, multiple signaling transduction pathways, important for stem cell proliferation and differentiations, are deregulated. Strategies are being developed to identify and characterize the liver cancer stem cells. Targeting liver cancer stem cells may bring hope to curing hepatocellular carcinoma.