Direction-dependent resistance to flow in the endplate of the intervertebral disc: an ex vivo study
Direction-dependent resistance to flow in the endplate of the intervertebral disc: an ex vivo study
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DOI：
10.1016/s0736-0266(01)00038-9
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发表时间：
2001-11-01
影响因子：
2.8
通讯作者：
Tepic, S
中科院分区：
文献类型：
--
作者：
Ayotte, DC;Ito, K;Tepic, S
将日常负荷期间健康椎间盘核中较高的静水压力与休息期间椎间盘中相对较低的渗透膨胀压进行比较，表明存在方向依赖性流动阻力，使得负荷期间从椎间盘渗出的所有液体在休息期间恢复。在这项研究中，这种方向依赖性阻力被证明是通过软骨终板和骨终板中的骨髓接触通道的流动。使用离体绵羊终板模型，通过终板的流动阻力比（R-out/R-in）为39.0 +/- 3.8（平均值+/- S.E.）。此外，使用荧光染色显示了通过骨髓接触孔的液体流动路径。(C)2001骨科研究学会。由爱思唯尔科技有限公司出版。保留所有权利。
A comparison of the higher hydrostatic pressure in the nucleus of the healthy intervertebral disc during daily loading with the relatively lower osmotic swelling pressure in the disc during rest suggests the existence of direction-dependent flow resistance such that all of the fluid exuded from the disc during loading is recovered during rest. In this study, this direction-dependent resistance was demonstrated for flows through the cartilage endplates and the underlying marrow contact channels in the bony endplates. Using an ex vivo sheep endplate model, the resistance ratio (R-out/R-in) for flow through the endplate was 39.0 +/- 3.8 (mean +/- S.E.). In addition, a path of fluid flow through the marrow contact holes was revealed using fluorescent staining. (C) 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.