A selective optical sensor based on [9]mercuracarborand-3, a new type of ionophore with a chloride complexing cavity
A selective optical sensor based on [9]mercuracarborand-3, a new type of ionophore with a chloride complexing cavity
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DOI：
10.1021/ac000508k
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发表时间：
2000-09-15
影响因子：
7.4
通讯作者：
Bachas, LG
中科院分区：
文献类型：
--
作者：
Badr, IHA;Johnson, RD;Bachas, LG
本文描述了一种基于多齿路易斯酸离子载体[9]mercuracarborand-3的高选择性氯离子光学传感器。该传感器是通过将 Mercuracarborand 离子载体、合适的 pH 敏感亲脂性染料和亲脂性阳离子位点嵌入塑化聚合物膜中而构建的。 [9]mercuracarborand-3 的预组织络合腔提供的多重互补相互作用可控制光学薄膜的阴离子选择性模式。该薄膜对氯离子的选择性显着高于各种亲脂性阴离子，例如高氯酸根、硝酸根、水杨酸根和硫氰酸根。此外，与之前报道的氯离子光学传感器不同，与其他生物相关阴离子相比，获得的氯离子光学选择性系数满足测定生理液体中氯离子的选择性要求。此外，该光学薄膜在较宽的动态范围（16 μM-136 mM）内可逆地响应氯化物，具有快速响应和恢复时间。
A highly selective optical sensor for chloride, based on the multidentate Lewis acid ionophore [9]mercuracarborand-3, is described herein. This sensor is constructed by embedding the mercuracarborand ionophore, a suitable pH-sensitive lipophilic dye, and lipophilic cationic sites in a plasticized polymeric membrane. The multiple complementary interactions offered by the preorganized complexing cavity of [9]mercuracarborand-3 is shown to control the anion selectivity pattern of the optical film. The film exhibits a significantly enhanced selectivity for chloride over a variety of lipophilic anions such as perchlorate, nitrate, salicylate, and thiocyanate. Furthermore, the optical selectivity coefficients obtained for chloride over other biologically relevant anions are shown to meet the selectivity requirements for the determination of chloride in physiological fluids, unlike previously reported chloride optical sensors. In addition, the optical film responds to chloride reversibly over a wide dynamic range (16 mu M-136 mM) with fast response and recovery times.