A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction
A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction
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DOI：
10.4065/82.11.1341
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发表时间：
2007-11-01
影响因子：
8.9
通讯作者：
Sy, Lina S.
中科院分区：
文献类型：
--
作者：
Yawn, Barbara P.;Saddier, Patricia;Sy, Lina S.
目的：建立准确的、最新的、基线流行病学数据带状疱疹（HZ）引入之前，最近批准的HZ疫苗。使用1996年1月1日至2005年10月15日的数据，我们对成年居民进行了基于人群的研究（222岁），以确定（通过病历审查）HZ的发病率和HZ相关并发症的发生率。发病率确定的年龄和性别，并调整到美国population.RESULTS：1669年1月1日，1996年，2001年12月31日之间确定了确诊HZ的成年居民。这些患者中的大多数（92%）具有免疫功能，60%为女性。根据美国成人人群调整后，HZ的发生率为3.6/1000人-年（95%置信区间，3.4-3.7），从1996年至2001年，HZ的发生率从3.2/1000人-年增加至4.1/1000人-年。HZ的发生率和HZ相关并发症的发生率随年龄增加而增加，68%的病例发生在50岁及以上的患者中。带状疱疹后遗神经痛发生在18%的成人患者和33%的79岁及以上的患者。总体而言，10%的所有患者与HZ经历了1个或多个nonpain complications.CONCLUSIONS：我们的人口为基础的数据表明，HZ主要影响免疫功能正常的成年人年龄大于50岁，1在4的经验，某种类型的HZ相关的并发症。
OBJECTIVE: To establish accurate, up-to-date, baseline epidemiological data for herpes zoster (HZ) before the introduction of the recently licensed HZ vaccine.METHODS: Using data from January 1, 1996, to October 15, 2005, we conducted a population-based study of adult residents (222 years) of Olmsted County, MN, to determine (by medical record review) the incidence of HZ and the rate of HZ-related complications. Incidence rates were determined by age and sex and adjusted to the US population.RESULTS: A total of 1669 adult residents with a confirmed diagnosis of HZ were identified between January 1, 1996, and December 31, 2001. Most (92%) of these patients were immunocompetent and 60% were women. When adjusted to the US adult population, the incidence of HZ was 3.6 per 1000 person-years (95% confidence interval, 3.4-3.7), with a temporal increase from 3.2 to 4.1 per 1000 person-years from 1996 to 2001. The incidence of HZ and the rate of HZ-associated complications increased with age, with 68% of cases occurring in those aged 50 years and older. Postherpetic neuralgia occurred in 18% of adult patients with HZ and in 33% of those aged 79 years and older. Overall, 10% of all patients with HZ experienced 1 or more nonpain complications.CONCLUSIONS: Our population-based data suggest that HZ primarily affects immunocompetent adults older than 50 years; 1 in 4 experiences some type of HZ-related complication.