ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson's disease.
ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson's disease.
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DOI：
10.3389/fncel.2013.00004
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发表时间：
2013
影响因子：
5.3
通讯作者：
Nawa H
中科院分区：
文献类型：
--
作者：
Iwakura Y;Nawa H
ErbB1-4受体酪氨酸激酶的配体，如表皮生长因子(EGF)和神经调节蛋白，调节大脑的发育和功能。因此，它们信号的异常与精神分裂症和帕金森病的病因或病理有关。在ErbB受体中，ErbB1和ErbB4在多巴胺和GABA神经元中表达，ErbB1、2和/或3主要在少突胶质细胞、星形胶质细胞及其前体细胞中表达。因此，ErbB信号的缺陷可能导致由这些细胞类型引起的神经和精神疾病。通过结合最新的癌症分子生物学以及我们的最新进展，我们讨论了ErbB1-4亚基之间的信号串扰及其在每种细胞类型中的神经生物学功能。还讨论了病毒衍生的细胞因子(病毒因子)在脑部疾病中的潜在作用，这些细胞因子模仿EGF和NeuRegin-1。
Ligands for ErbB1-4 receptor tyrosine kinases, such as epidermal growth factor (EGF) and neuregulins, regulate brain development and function. Thus, abnormalities in their signaling are implicated in the etiology or pathology of schizophrenia and Parkinson's disease. Among the ErbB receptors, ErbB1, and ErbB4 are expressed in dopamine and GABA neurons, while ErbB1, 2, and/or 3 are mainly present in oligodendrocytes, astrocytes, and their precursors. Thus, deficits in ErbB signaling might contribute to the neurological and psychiatric diseases stemming from these cell types. By incorporating the latest cancer molecular biology as well as our recent progress, we discuss signal cross talk between the ErbB1-4 subunits and their neurobiological functions in each cell type. The potential contribution of virus-derived cytokines (virokines) that mimic EGF and neuregulin-1 in brain diseases are also discussed.
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