Topography and physiology of ascending streams in the auditory tectothalamic pathway
Topography and physiology of ascending streams in the auditory tectothalamic pathway
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DOI：
10.1073/pnas.0907873107
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发表时间：
2010-01-05
影响因子：
11.1
通讯作者：
Sherman, S. Murray
中科院分区：
文献类型：
--
作者：
Lee, Charles C.;Sherman, S. Murray
听觉信息从耳蜗沿沿着通路传递，并到达下丘（IC）和内侧膝状体（MGB），然后到达皮层。虽然上升tectothalamic途径腹侧司的MGB被认为是一个高保真的信息承载渠道，的作用途径的背侧和内侧司是更不透明的。在这里，我们使用体外切片制备显示这些上行途径之间的根本差异。使用光刺激，我们发现了三种主要的输入模式（兴奋性，抑制性和混合），在每个途径不同。此外，中央核的IC的电刺激引起的MGB中的抑郁症的反应，没有代谢型谷氨酸（mGlu）受体成分，而刺激的IC的外侧皮质引起的促进反应与mGlu受体成分。这些数据表明，顶盖丘脑上行通路在功能上彼此不同。
Auditory information is relayed from the cochlea along parallel pathways and reaches the inferior colliculus (IC) and the medial geniculate body (MGB) en route to the cortex. Although the ascending tectothalamic pathway to the ventral division of the MGB is regarded as a high-fidelity information-bearing channel, the roles of the pathways to the dorsal and medial divisions are more opaque. Here, we show fundamental differences between these ascending pathways using an in vitro slice preparation. Using photostimulation, we found three main patterns of input (excitatory, inhibitory, and mixed) that differed in each pathway. Furthermore, electrical stimulation of the central nucleus of the IC evoked a depressing response in the MGB with no metabotropic glutamate (mGlu) receptor component, whereas stimulation of the lateral cortex of the IC evoked a facilitating response with an mGlu receptor component. These data suggest that the ascending tectothalamic pathways are functionally distinct from one another.