X chromosome and suicide
X chromosome and suicide
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DOI：
10.1038/mp.2009.132
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发表时间：
2011-02-01
影响因子：
11
通讯作者：
Turecki, G.
中科院分区：
文献类型：
--
作者：
Fiori, L. M.;Zouk, H.;Turecki, G.
在大多数社会中，男性的自杀完成率明显高于女性。虽然自杀率的性别差异部分是由环境和行为因素解释的，但遗传因素通过性别之间的差异表达也可能有助于解释自杀风险的性别适度。本研究采用两步策略调查自杀完成者中的X连锁基因。我们首先利用了法裔加拿大人的遗传结构，并对722名不相关的法裔加拿大男性受试者进行了基因分型，其中333人为自杀完成者，389人为非自杀对照，使用了一组跨越整个X染色体的37个微卫星标记。9个单倍型窗口和几个个体标记与自杀相关。显著结果主要聚集在两个区域，一个在X染色体的长臂，另一个在短臂，分别由标记DXS 8051和DXS 8102，以及DXS 1001和DXS 8106限制。研究的第二阶段调查了在自杀完成者和对照组的独立样本中，映射到Brodmann区域8/9，11，44和46的相关区域的基因的差异脑表达。在这些区域内的六个基因，Rho GTP酶激活蛋白6，衔接子相关蛋白复合物1 σ 2亚基，糖蛋白M6 B，核糖体蛋白S6激酶90 kDa多肽3，亚精胺/精胺N（1）-乙酰转移酶1和THO复合物2，被发现在自杀完成者中差异表达。Molecular Psychiatry（2011）16，216-226; doi：10.1038/mp.2009.132; 2009年12月15日在线发表
Suicide completion rates are significantly higher in males than females in most societies. Although gender differences in suicide rates have been partially explained by environmental and behavioral factors, it is possible that genetic factors, through differential expression between genders, may also help explain gender moderation of suicide risk. This study investigated X-linked genes in suicide completers using a two-step strategy. We first took advantage of the genetic structure of the French-Canadian population and genotyped 722 unrelated French-Canadian male subjects, of whom 333 were suicide completers and 389 were non-suicide controls, using a panel of 37 microsatellite markers spanning the entire X chromosome. Nine haplotype windows and several individual markers were associated with suicide. Significant results aggregated primarily in two regions, one in the long arm and another in the short arm of chromosome X, limited by markers DXS8051 and DXS8102, and DXS1001 and DXS8106, respectively. The second stage of the study investigated differential brain expression of genes mapping to associated regions in Brodmann areas 8/9, 11, 44 and 46, in an independent sample of suicide completers and controls. Six genes within these regions, Rho GTPase-activating protein 6, adaptor-related protein complex 1 sigma 2 subunit, glycoprotein M6B, ribosomal protein S6 kinase 90 kDa polypeptide 3, spermidine/spermine N(1)-acetyltransferase 1 and THO complex 2, were found to be differentially expressed in suicide completers. Molecular Psychiatry (2011) 16, 216-226; doi:10.1038/mp.2009.132; published online 15 December 2009