Prenatal exposure to organomercury, thimerosal, persistently impairs the serotonergic and dopaminergic systems in the rat brain: Implications for association with developmental disorders
Prenatal exposure to organomercury, thimerosal, persistently impairs the serotonergic and dopaminergic systems in the rat brain: Implications for association with developmental disorders
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DOI：
10.1016/j.braindev.2012.05.004
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发表时间：
2013-03-01
影响因子：
1.7
通讯作者：
Narita, Masaaki
中科院分区：
文献类型：
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作者：
Ida-Eto, Michiru;Oyabu, Akiko;Narita, Masaaki
硫柳汞是一种有机汞化合物，已被广泛用作防腐剂。因此，人们对其神经毒性表示担忧。我们最近证明了产前暴露于硫柳汞对早期多巴胺能发育的干扰（Shakespe-Eto et al.（2011）[11]）。在这里，我们调查了产前硫柳汞暴露是否会导致出生后的持续性损伤。出生后第50天的分析显示，在胚胎第9天给予硫柳汞后，海马5-羟色胺显著增加。此外，不仅血清素，纹状体多巴胺显着增加。这些结果表明，胚胎暴露于硫柳汞会对脑单胺能系统产生持久的损害，因此应尽一切努力避免使用硫柳汞。(C)2012年日本儿童神经病学学会。Elsevier B. V.出版，保留所有权利。
Thimerosal, an organomercury compound, has been widely used as a preservative. Therefore, concerns have been raised about its neurotoxicity. We recently demonstrated perturbation of early serotonergic development by prenatal exposure to thimerosal (Ida-Eto et al. (2011) [11]). Here, we investigated whether prenatal thimerosal exposure causes persistent impairment after birth. Analysis on postnatal day 50 showed significant increase in hippocampal serotonin following thimerosal administration on embryonic day 9. Furthermore, not only serotonin, striatal dopamine was significantly increased. These results indicate that embryonic exposure to thimerosal produces lasting impairment of brain monoaminergic system, and thus every effort should be made to avoid the use of thimerosal. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.