LOCALIZED H-1-NMR MEASUREMENTS OF GAMMA-AMINOBUTYRIC-ACID IN HUMAN BRAIN INVIVO
LOCALIZED H-1-NMR MEASUREMENTS OF GAMMA-AMINOBUTYRIC-ACID IN HUMAN BRAIN INVIVO
复制标题
DOI：
10.1073/pnas.90.12.5662
复制
发表时间：
1993-06-15
影响因子：
11.1
通讯作者：
MATTSON, RH
中科院分区：
文献类型：
--
作者：
ROTHMAN, DL;PETROFF, OAC;MATTSON, RH
使用局部H-1 NMR光谱结合J编辑来测量四名对照人类志愿者和四名接受药物氨己烯酸的癫痫志愿者的枕叶中γ-氨基丁酸（GABA）的浓度。在4名非癫痫受试者中测得的GABA浓度为1.1 +/- 0.1 mumol/cm 3的大脑，这与以前在手术切除的人类皮层中测得的值非常一致。在接受GABA转氨酶抑制剂氨己烯酸的患者中测量到GABA浓度的剂量依赖性升高，在研究的最高剂量（每天6 g）下测量到的最大测量水平为3.7 mumol/cm 3脑。 在那些接受GABA升高剂如氨己烯酸的患者中GABA的H-1 NMR测量将在建立癫痫发作抑制和脑GABA浓度之间的关系中具有重要意义。
Localized H-1 NMR spectroscopy in conjunction with J editing was used to measure the concentration of gamma-aminobutyric acid (GABA) in the occipital lobe of four control human volunteers and four epileptic volunteers who were receiving the drug vigabatrin. The GABA concentration measured in four nonepileptic subjects was 1.1 +/- 0.1 mumol/cm3 of brain, which is in good agreement with previous values measured in surgically removed human cortex. A dose-dependent elevation of GABA concentration was measured in patients receiving the GABA transaminase inhibitor vigabatrin, with the maximum measured level of 3.7 mumol/cm3 of brain measured at the highest dose (6 g per day) studied. H-1 NMR measurements of GABA in those patients receiving GABA-elevating agents such as vigabatrin will be of importance in establishing the relationship between seizure suppression and the concentration of brain GABA.