Clinical effect of rabbit anti-thymocyte globulin for chronic active antibody-mediated rejection after kidney transplantation
Clinical effect of rabbit anti-thymocyte globulin for chronic active antibody-mediated rejection after kidney transplantation
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兔抗胸腺细胞球蛋白治疗肾移植后慢性活动性抗体介导排斥反应的临床效果
DOI：
10.1007/s13730-021-00633-7
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发表时间：
2021
期刊：
影响因子：
1
通讯作者：
Takao Tetsuya
中科院分区：
文献类型：
--
作者：
Tanaka Ryo;Tsutahara Koichi;Inoguchi Shunsuke;Horitani Hiromu;Asakura Toshihisa;Kawamura Norihiko;Kakuta Yoichi;Nakagawa Masahiro;Takao Tetsuya
慢性活性抗体介导的排斥反应（CAAMR）是晚期移植物丢失的常见原因。然而，肾移植后CAAMR的有效治疗尚未建立。在这里，我们提出的情况下，肾移植受者谁恢复CAAMR后，兔抗胸腺细胞球蛋白管理。一名61岁的男性因终末期肾病接受ABO相容性活体供肾移植;肾脏由他的妻子捐赠。移植后五年，患者的血清肌酐水平和尿蛋白与肌酐的比值增加。随后，基于肾移植活检和供体特异性人类白细胞抗原抗体的存在，他被诊断为CAAMR。类固醇脉冲治疗后给予兔抗胸腺细胞球蛋白治疗。随后，他的血清肌酐水平和尿蛋白与肌酐的比值得到改善。活检病理结果和供体特异性抗体的平均荧光强度也有所改善。总之，本报告描述了一例肾移植受者发生CAAMR，使用兔抗胸腺细胞球蛋白治疗。这种策略可能是肾移植后CAAMR的一种可行的治疗选择。
Chronic active antibody-mediated rejection (CAAMR) is a frequent cause of late graft loss. However, effective treatment for CAAMR after kidney transplantation has not yet been established. Here, we present the case of a kidney transplant recipient who recovered from CAAMR after administration of rabbit anti-thymocyte globulin. A 61-year-old man underwent ABO-compatible living-donor kidney transplantation for end-stage kidney disease; the kidney was donated by his wife. Five years after the transplant, the patient’s serum creatinine level and urine protein-to-creatinine ratio increased. He was subsequently diagnosed with CAAMR based on the kidney allograft biopsy and the presence of donor-specific human leukocyte antigen antibodies. Rabbit anti-thymocyte globulin treatment was administered following steroid pulse therapy. Subsequently, his serum creatinine levels and urine protein to creatinine ratio improved. There was also an improvement in the pathological findings seen on biopsy and the mean fluorescence intensity of donor-specific antibodies. In conclusion, this report describes the case of a kidney transplant recipient who developed CAAMR, treated using rabbit anti-thymocyte globulin. This strategy might be a viable treatment option for CAAMR after a kidney transplant.
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影响因子：
0.9
作者：
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通讯作者：
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