Associations of height, leg length, and lung function with cardiovascular risk factors in the Midspan Family Study
Associations of height, leg length, and lung function with cardiovascular risk factors in the Midspan Family Study
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DOI：
10.1136/jech.57.2.141
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发表时间：
2003-02-01
影响因子：
6.3
通讯作者：
Watt, GCM
中科院分区：
文献类型：
--
作者：
Gunnell, D;Whitley, E;Watt, GCM
背景：高个子和肺功能较好的人患冠心病的风险较低。这些关联的生物学机制尚不清楚，但这两种措施可能是早期生活暴露的标志。一些研究表明，腿长是青春期前营养状况的一个指标，是与冠心病风险关系最密切的身高组成部分。其他研究表明，当肺功能得到控制时，身高与冠心病的关联会大大减弱。本研究检验了(1)身高和身高组成部分（腿长和躯干长）与冠心病危险因素的关联，(2)身高和一秒用力呼气量（FEV1）与冠心病危险因素的相对关联强度。研究对象和方法：对1972-76年间父母接受心血管筛查的年龄在30-59岁之间的1040名男性和1298名女性的详细心血管筛查数据进行横断面分析。研究对象来自1477个家庭，是跨中年家庭研究的成员。背景：苏格兰西部的伦弗鲁镇和佩斯利镇。结果：较高的受试者和肺功能较好的受试者具有更有利的心血管危险因素，与FEV1的相关性最强。较高的FEV1与较低的血压、胆固醇、葡萄糖、纤维蛋白原、白细胞计数和体重指数有关。身高也有类似的关联，但通常较弱。这些关联在控制亲本身高的模型中没有减弱。较长的腿长与较低的收缩压和舒张压相关，但与躯干长度无关。与躯干长度相比，腿长的人胆固醇水平和身体质量指数也更高。结论：这些发现提供了间接证据，表明肺部发育和青春期前生长作为儿童暴露的生物标志物，可能会改变个体患冠心病的风险。基因影响似乎并不是身高与冠心病之间联系的基础。
Background: Taller people and those with better lung function are at reduced risk of coronary heart disease (CHD). Biological mechanisms for these associations are not well understood, but both measures may be markers for early life exposures. Some studies have shown that leg length, an indicator of pre-pubertal nutritional status, is the component of height most strongly associated with CHD risk. Other studies show that height-CHD associations are greatly attenuated when lung function is controlled for. This study examines (1) the association of height and the components of height (leg length and trunk length) with CHD risk factors and (2) the relative strength of the association of height and forced expiratory volume in one second (FEV1) with risk factors for CHD.Subjects and methods: Cross sectional analysis of data collected at detailed cardiovascular screening examinations of 1040 men and 1298 women aged 30-59 whose parents were screened in 1972-76. Subjects come from 1477 families and are members of the Midspan Family Study.Setting: The towns of Renfrew and Paisley in the West of Scotland.Results: Taller subjects and those with better lung function had more favourable cardiovascular risk factor profiles, associations were strongest in relation to FEV1. Higher FEV1 was associated with lower blood pressure, cholesterol, glucose, fibrinogen, white blood cell count, and body mass index. Similar, but generally weaker, associations were seen with height. These associations were not attenuated in models controlling for parental height. Longer leg length, but not trunk length, was associated with lower systolic and diastolic blood pressure. Longer leg length was also associated with more favourable levels of cholesterol and body mass index than trunk length.Conclusions: These findings provide indirect evidence that measures of lung development and pre-pubertal growth act as biomarkers for childhood exposure that may modify an individual's risk of developing CHD. Genetic influences do not seem to underlie height-CHD associations.