Caenorhabditis elegans:: how good a model for veterinary parasites?
Caenorhabditis elegans:: how good a model for veterinary parasites?
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DOI：
10.1016/s0304-4017(01)00562-3
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发表时间：
2001-11-22
影响因子：
2.6
通讯作者：
Thompson, DP
中科院分区：
文献类型：
--
作者：
Geary, TG;Thompson, DP
在分子水平上已知最多的生物体是线虫，自由生活的线虫。该生物体已成为发现驱虫药物和研究驱虫药物作用机制的合理模型。从对线虫的研究中也获得了关于驱虫剂抗性机制的有用信息。不幸的是，目前还没有大规模的扩展的遗传技术开发的线虫研究的寄生虫物种的兽医（或人类）寄生虫。通过研究C.线虫是线虫的主要寄生虫，但线虫寄生的基本生物学特性只能通过对多种寄生虫的比较研究来发现。(C)2001 Elsevier Science B.V.保留所有权利。
The organism about which most is known on a molecular level is a nematode, the free-living organism Caenorhabditis elegans. This organism has served as a reasonable model for the discovery of anthelmintic drugs and for research on the mechanism of action of anthelmintics. Useful information on mechanisms of anthelmintic resistance has also been obtained from studies on C elegans. Unfortunately, there has not been a large-scale extension of genetic techniques developed in C elegans to research on parasitic species of veterinary (or human) parasites. Much can be learned about the essentials of nematode biology by studying C. elegans, but discovering the basic biology of nematode parasitism can only be gained through comparative studies on multiple parasitic species. (C) 2001 Elsevier Science B.V. All rights reserved.