Copper(II)-catalyzed enantioselective intramolecular carboamination of alkenes
Copper(II)-catalyzed enantioselective intramolecular carboamination of alkenes
复制标题
DOI：
10.1021/ja0762240
复制
发表时间：
2007-10-31
影响因子：
15
通讯作者：
Chemler, Sherry R.
中科院分区：
文献类型：
--
作者：
Zeng, Wei;Chemler, Sherry R.
提出了用于合成氮杂环的γ-烯基芳基磺酰胺和δ-烯基芳基磺酰胺的对映选择性氧化环化。该反应由手性铜(II)络合物催化，MnO2 被用作廉价的化学计量氧化剂。多种五元杂环和四氢异喹啉已以良好至优异的产率合成，并且具有良好至优异的对映选择性水平。这是首次报道铜催化烯烃的对映选择性碳胺化反应。
The enantioselective oxidative cyclizations of gamma-alkenyl arylsulfonamides and a delta-alkenyl arylsulfonamide for the synthesis of nitrogen heterocycles are presented. The reactions are catalyzed by chiral copper(II) complexes, and MnO2 is used as the inexpensive stoichiometric oxidant. A variety of five-membered heterocycles and a tetrahydroisoquinoline have been synthesized in good to excellent yields with good to excellent levels of enantioselectivity. This is the first reported copper-catalyzed enantioselective carboamination of alkenes.