New chiral amino alcohol ligands derived from 1-phenylethylamine for efficient Ru-catalyzed asymmetric transfer hydrogenation
New chiral amino alcohol ligands derived from 1-phenylethylamine for efficient Ru-catalyzed asymmetric transfer hydrogenation
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源自 1-苯乙胺的新型手性氨基醇配体用于高效 Ru 催化不对称转移氢化
DOI：
10.1016/j.tetasy.2011.01.017
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发表时间：
2011-01-31
影响因子：
--
通讯作者：
Zheng, Zhuo
中科院分区：
文献类型：
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作者：
Han, Mei-Ling;Hu, Xiang-Ping;Zheng, Zhuo
A series of chiral amino alcohols have been prepared from cheap and readily available (S)-1-phenylethylamine through a one-step transformation. The ability of these newly developed amino alcohols as chiral ligands was evaluated in the Ru-catalyzed asymmetric transfer hydrogenation of aromatic alkyl ketones, providing chiral secondary alcohols with good to excellent conversions (71-100%) and moderate to good enantioselectivities (67-95% ee). The results also showed that the structure of these amino alcohols has a significant influence on the conversion and enantioselectivity. (C) 2011 Elsevier Ltd. All rights reserved.
