Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.
Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.
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DOI：
10.1016/j.ceb.2018.05.016
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发表时间：
2018-10
影响因子：
7.5
通讯作者：
LaBarge MA
中科院分区：
文献类型：
--
作者：
Todhunter ME;Sayaman RW;Miyano M;LaBarge MA
老化是由不可避免的熵力驱动的，物理化学性质，破坏了构成生物系统的原材料。单细胞经历并响应于随机物理化学损伤，这些随机物理化学损伤以动态和相互的方式发生在细胞本身或其微环境中，导致增加的年龄相关的细胞间变异。我们将讨论生物学机制，整合跨组织细胞间的变化，导致刻板的年龄表型。
Aging is driven by unavoidable entropic forces, physicochemical in nature, that damage the raw materials that constitute biological systems. Single cells experience and respond to stochastic physicochemical insults that occur either to the cells themselves or to their microenvironment, in a dynamic and reciprocal manner, leading to increased age-related cell-to-cell variation. We will discuss the biological mechanisms that integrate cell-to-cell variation across tissues resulting in stereotypical phenotypes of age.
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影响因子：
64.5
作者：
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Quake SR
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3.7
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van Deursen JM
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影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
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Zhang, Kang
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16.6
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Grover A;Sanjuan-Pla A;Thongjuea S;Carrelha J;Giustacchini A;Gambardella A;Macaulay I;Mancini E;Luis TC;Mead A;Jacobsen SE;Nerlov C
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Nerlov C