(+)cis-dioxolane stimulation of cytosolic calcium oscillations and phasic contractions of myometrial smooth muscle.
(+)cis-dioxolane stimulation of cytosolic calcium oscillations and phasic contractions of myometrial smooth muscle.
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( )顺式二氧戊环刺激细胞质钙振荡和子宫肌层平滑肌的阶段性收缩。
DOI：
10.1006/bbrc.1997.6163
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Basa,A
中科院分区：
文献类型：
--
作者：
Phillippe,M;Basa,A
这些研究试图确定毒蕈碱受体刺激肌平滑肌阶段性收缩的细胞内机制。利用加载Fura-2的肌条的细胞质钙成像研究，以及体外等量收缩研究，我们证明了（+）顺式二氧唑烷（一种毒蕈碱选择性乙酰胆碱激动剂）刺激的相性肌收缩是通过M3受体亚型的激活介导的，导致磷脂酰肌醇信号通路的刺激和细胞质钙振荡的产生。
These studies sought to determine the intracellular mechanisms underlying muscarinic receptor stimulated phasic contractions of myometrial smooth muscle. Utilizing cytosolic calcium imaging studies with Fura-2 loaded muscle strips, along within vitroisometric contraction studies, we have demonstrated that phasic myometrial contractions stimulated in response to (+)cis-dioxolane, a muscarinic selective acetylcholine agonist, are mediated by activation of the M3 receptor subtype resulting in stimulation of the phosphatidylinositol signaling pathway and the generation of cytosolic calcium oscillations.