LONG-TERM SEQUELAE OF ROCKY-MOUNTAIN-SPOTTED-FEVER
LONG-TERM SEQUELAE OF ROCKY-MOUNTAIN-SPOTTED-FEVER
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DOI：
10.1093/clinids/20.5.1122
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发表时间：
1995-05-01
影响因子：
11.8
通讯作者：
SEXTON, DJ
中科院分区：
文献类型：
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作者：
ARCHIBALD, LK;SEXTON, DJ
从我们的105例患者数据库中确定了25例确诊或疑似落基山斑疹热（RMSF）患者，这些患者住院时间大于或等于2周。通过电话和/或病历收集了20例患者的随访信息，其余5例患者失访或死亡。9例患者有大于或等于1例长期后遗症（定义为出院后持续大于或等于1年的与立克次体原始急性感染相关的并发症），有后遗症患者的年龄范围为2至74岁（平均值和中位数为38岁）;随访时间范围为1至18年（平均值为11年）。有和无长期后遗症患者的平均住院时间分别为47天和20天（P <0.05）。长期神经系统后遗症包括下肢轻瘫、听力丧失、周围神经病变、膀胱和肠失禁、小脑、前庭和运动功能障碍以及语言障碍。非神经系统后遗症包括肢体截肢和皮肤坏死后阴囊疼痛造成的残疾。这些数据表明，由于RMSF而患有严重疾病的患者中常见显著的长期发病率。
Twenty-five patients with definite or probable Rocky Mountain spotted fever (RMSF) who were hospitalized for greater than or equal to 2 weeks were identified from our database of 105 patients. Follow-up information was collected for 20 patients, per telephone and/or medical records, The remaining five patients were lost to follow-up or died. Nine patients had greater than or equal to 1 long-term sequelae (defined as complications related to an original acute infection with Rickettsia rickettsii that persisted for greater than or equal to 1 year following hospital discharge), The ages of patients with sequelae ranged from 2 to 74 years (mean and median, 38 years); duration of follow-up ranged from 1 to 18 years (mean, Il years). The mean lengths of hospitalization for patients with and without long-term sequelae were 47 days and 20 days, respectively (P < .05). Long-term neurological sequelae included paraparesis; hearing loss; peripheral neuropathy; bladder and bowel incontinence; cerebellar, vestibular, and motor dysfunction; and language disorders. Nonneurological sequelae consisted of disability from limb amputation and scrotal pain following cutaneous necrosis. These data suggest that significant long-term morbidity is common in patients with severe illness due to RMSF.