Imprinted genes in mouse placental development and the regulation of fetal energy stores.
Imprinted genes in mouse placental development and the regulation of fetal energy stores.
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DOI：
10.1530/rep-12-0511
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发表时间：
2013-05
期刊：
影响因子：
3.8
通讯作者：
Simon James Tunster;A. Jensen;R. John
中科院分区：
文献类型：
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作者：
Simon James Tunster;A. Jensen;R. John
印迹基因，其作为生殖系中的表观遗传事件的结果优先从一个或其他亲本染色体表达，已知在功能上会聚于使哺乳动物在子宫内发育成为可能的生物过程。在小鼠中已经鉴定出超过100个印记基因，其中大多数在胎盘中表达和印记。本文综述了小鼠胎盘中印迹基因功能的研究进展。很少有印记基因被评估其在胎盘中的剂量相关作用。尽管如此，目前的数据表明，印记基因集中在胎盘的两个关键功能，营养运输和胎盘信号。对小鼠的研究可以更好地了解某些人类病理学，包括低出生体重和成年代谢疾病的规划，以及妊娠并发症，如先兆子痫和妊娠糖尿病，由胎儿携带异常印记引起。
Imprinted genes, which are preferentially expressed from one or other parental chromosome as a consequence of epigenetic events in the germline, are known to functionally converge on biological processes that enable in utero development in mammals. Over 100 imprinted genes have been identified in the mouse, the majority of which are both expressed and imprinted in the placenta. The purpose of this review is to provide a summary of the current knowledge regarding imprinted gene function in the mouse placenta. Few imprinted genes have been assessed with respect to their dosage-related action in the placenta. Nonetheless, current data indicate that imprinted genes converge on two key functions of the placenta, nutrient transport and placental signalling. Murine studies may provide a greater understanding of certain human pathologies, including low birth weight and the programming of metabolic diseases in the adult, and complications of pregnancy, such as pre-eclampsia and gestational diabetes, resulting from fetuses carrying abnormal imprints.