Development and Potential Theranostic Applications of a Self-Assembled Hybrid of Magnetic Nanoparticle Clusters with Polysaccharide Nanogels
Development and Potential Theranostic Applications of a Self-Assembled Hybrid of Magnetic Nanoparticle Clusters with Polysaccharide Nanogels
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DOI：
10.1002/cplu.201402159
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发表时间：
2014-11-01
期刊：
影响因子：
3.4
通讯作者：
Akiyoshi, Kazunari
中科院分区：
文献类型：
--
作者：
Katagiri, Kiyofumi;Ohta, Keiko;Akiyoshi, Kazunari
通过纳米聚合物水凝胶(纳米凝胶)和纳米Fe3O4纳米粒子(NPs)的自组装，形成了一种新型的有机-无机杂化材料，具有潜在的生物医学应用价值。采用四氢呋喃(THF)注射法制备了疏水性Fe3O4纳米粒子，通过疏水作用将其与两亲多糖纳米凝胶复合。所得杂化产物具有较高的胶体稳定性和在水介质中的分散性。通过改变Fe3O4纳米粒子在四氢呋喃中的浓度来控制Fe3O4纳米粒子的聚集数量。在T-2磁共振成像中，由于纳米Fe3O4纳米粒子与纳米凝胶络合后的最佳团聚，这种杂化材料显示出比现有造影剂更大的增强效果。此外，混合动力车还能在交变磁场照射下产生热量。通过调节混合体的浓度和磁场的幅值来控制温度的升高，表明混合体同样适用于磁热治疗。
A new organicinorganic hybrid was generated by self-assembly of nanosized polymer hydrogels (nanogels) and Fe3O4 nanoparticles (NPs) for potential biomedical applications. By using the tetrahydrofuran (THF) injection method, hydrophobized Fe3O4 NPs were complexed through hydrophobic interactions with amphiphilic polysaccharide nanogels. The obtained hybrid showed high colloidal stability and dispersibility in aqueous media. The number of Fe3O4 NP aggregates was controlled by changing the concentration of the Fe3O4 NPs in THF. The hybrid displayed greater enhancement than existing contrast media in T-2 magnetic resonance imaging because of the optimal agglomeration of Fe3O4 NPs following their complexation with nanogels. Furthermore, the hybrid generated heat in response to alternating magnetic-field irradiation. The increase in temperature was controlled by adjusting the concentration of the hybrid and the amplitude of the magnetic field, which indicates that the hybrid is also suitable for magnetic hyperthermia therapy.