Meibomian gland studies: histologic and ultrastructural investigations.
Meibomian gland studies: histologic and ultrastructural investigations.
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DOI：
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发表时间：
1981-04
影响因子：
4.4
通讯作者：
J. Jester;N. Nicolaides;R. E. Smith
中科院分区：
文献类型：
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作者：
J. Jester;N. Nicolaides;R. E. Smith
对睑板腺功能障碍的高度关注促使我们评估睑板腺的正常形态学和超微结构特征。对人类、灵长类动物、阉牛和兔的腺体进行组织学分析，发现角化上皮在整个睑板腺管中延伸的证据。在灵长类动物和兔腺体中鉴定的角化上皮的特征性超微结构特征包括张力细丝、透明角质颗粒、板层体和角化鳞状细胞。睑板腺导管与毛囊皮脂腺管和皮脂腺导管的比较显示了某些不同之处，如（1）缺乏发育良好的颗粒层和（2）从导管到腺泡的过渡细胞内缺乏脂质内含物。我们推测角质化过程的异常可能是睑板腺功能障碍状态的原因。
Heightened interest in meibomian gland dysfunction has prompted us to evaluate the normal morphological and ultrastructural characteristics of the meibomian gland. Histologic analysis of human, primate, steer, and rabbit glands revealed evidence of keratinized epithelium extending throughout the meibomian gland duct. Characteristic ultrastructural features of keratinized epithelium identified in primate and rabbit glands included tonofilaments, keratohyaline granules, lamellar bodies, and keratinized squamous cells. Comparison of the meibomian gland duct to the pilosebaceous canal and the sebaceous duct brought out certain dissimilarities such as (1) the lack of a well-developed stratum granulosum and (2) the absence of lipid inclusions within transitional cells from duct to acini. We postulate that abnormalities of the keratinizing process may be responsible for meibomian gland dysfunction states.