Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness?
Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness?
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DOI：
10.1016/j.biosystems.2010.07.009
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发表时间：
2010-10-01
期刊：
影响因子：
1.6
通讯作者：
Knibbe, C.
中科院分区：
文献类型：
--
作者：
Beslon, G.;Parsons, D. P.;Knibbe, C.
在过去的几年里，许多研究项目都集中在识别和理解原核生物基因组基因含量的尺度特性及其调控网络的复杂性。然而，尽管可用的数据越来越多，但这些缩放的起源仍然是一个悬而未决的问题。RAevol模型，一个数字遗传学模型，为我们提供了一个深入了解进化过程中涉及的机制。我们在这里提出的结果表明：(i)我们的模型定性地再现了这些比例定律，（ii）这些定律不是由于生活方式的差异，而是由于突变和重排的自发率的差异。我们认为，这是由于对健壮性的间接选择压力限制了基因组的大小。2010爱思唯尔爱尔兰有限公司版权所有。
In the past few years, numerous research projects have focused on identifying and understanding scaling properties in the gene content of prokaryote genomes and the intricacy of their regulation networks. Yet, and despite the increasing amount of data available, the origins of these scalings remain an open question. The RAevol model, a digital genetics model, provides us with an insight into the mechanisms involved in an evolutionary process. The results we present here show that (i) our model reproduces qualitatively these scaling laws and that (ii) these laws are not due to differences in lifestyles but to differences in the spontaneous rates of mutations and rearrangements. We argue that this is due to an indirect selective pressure for robustness that constrains the genome size. (C) 2010 Elsevier Ireland Ltd. All rights reserved.