Characteristics and feasibility of ambulatory respiratory assessment of paediatric neuromuscular disease: an observational retrospective study
Characteristics and feasibility of ambulatory respiratory assessment of paediatric neuromuscular disease: an observational retrospective study
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DOI：
10.1080/00207454.2022.2042691
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发表时间：
2022-03
影响因子：
2.2
通讯作者：
Cheng Zhang;C. Wei;Zhe Jin;Jing Ma;Yane Shen;Qing Yu;Yanbin Fan;H. Xiong;C. Que
中科院分区：
文献类型：
--
作者：
Cheng Zhang;C. Wei;Zhe Jin;Jing Ma;Yane Shen;Qing Yu;Yanbin Fan;H. Xiong;C. Que
摘要目的探讨神经肌肉病（NMD）患儿早期呼吸道受累的特点及简便的监测方法。材料与方法NMD患儿（年龄15岁/h或SpO 2 <90%持续时间≥ 60 min，FVC <51%）的预测值分别为75.8%和85.7%。结论PSG检查中AHI和缺氧负荷是NMD患儿的独立危险因素，应引起重视。FVC可能是严重睡眠呼吸障碍或缺氧的日间预测因子。夜间连续血氧饱和度测定结合昼夜峰流量测定可方便有效地用于呼吸系统受累早期的家庭监测。
Abstract Purpose To investigate the characteristics of respiratory involvement in Chinese paediatric neuromuscular disease (NMD) at early stage and to explore convenient monitoring methods. Materials and methods Children with NMD (age 15/h or duration of SpO2<90% ≥ 60 min from FVC <51% pred was 75.8% and 85.7%, respectively. Conclusions AHI and hypoxia burden were independent factors in children with NMD in PSG and attention needed to be paid in both. FVC might be a daytime predictor for significant sleep-disordered breathing or hypoxia. Nocturnal consecutive oximetry with diurnal peak flow measurement may be convenient and effective for home monitoring at early stage of respiratory involvement.