Peripheral neuropathy due to vitamin deficiency, toxins, and medications.
Peripheral neuropathy due to vitamin deficiency, toxins, and medications.
复制标题
DOI：
10.1212/01.con.0000455880.06675.5a
复制
发表时间：
2014-10-01
期刊：
影响因子：
--
通讯作者：
Windebank, Anthony J
中科院分区：
文献类型：
--
作者：
Staff, Nathan P;Windebank, Anthony J
审查目的：经常考虑继发于维生素缺乏、药物或毒素的周围神经病变，但难以明确诊断。准确的诊断很重要，因为这些疾病通常是可以治疗和预防的。本文综述了这些病因引起的不同类型的神经病变的主要特点，并提供了一个全面的清单，具体的代理人，必须牢记。最近的发现：虽然大多数代理人，导致周围神经病变已被称为多年，新开发的药物，导致周围神经病变进行了讨论。周围神经容易受到各种毒素、药物和维生素缺乏的损害。当接近有各种神经病变表现的患者时，考虑这些病因是很重要的;此外，其他全身症状可能提供病因线索。虽然长度依赖性感觉运动轴突周围神经病变是最常见的表现，但有几个例子以亚急性严重的方式出现，模仿格林-巴利综合征。
PURPOSE OF REVIEW: Peripheral neuropathies secondary to vitamin deficiencies, medications, or toxins are frequently considered but can be difficult to definitively diagnose. Accurate diagnosis is important since these conditions are often treatable and preventable. This article reviews the key features of different types of neuropathies caused by these etiologies and provides a comprehensive list of specific agents that must be kept in mind.RECENT FINDINGS: While most agents that cause peripheral neuropathy have been known for years, newly developed medications that cause peripheral neuropathy are discussed.SUMMARY: Peripheral nerves are susceptible to damage by a wide array of toxins, medications, and vitamin deficiencies. It is important to consider these etiologies when approaching patients with a variety of neuropathic presentations; additionally, etiologic clues may be provided by other systemic symptoms. While length-dependent sensorimotor axonal peripheral neuropathy is the most common presentation, several examples present in a subacute severe fashion, mimicking Guillain-Barre syndrome.