Nicotine withdrawal and craving in adolescents: Effects of sex and hormonal contraceptive use
Nicotine withdrawal and craving in adolescents: Effects of sex and hormonal contraceptive use
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DOI：
10.1016/j.addbeh.2009.03.033
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发表时间：
2009-06-01
影响因子：
4.4
通讯作者：
Hatsukami, Dorothy K.
中科院分区：
文献类型：
--
作者：
Dickmann, Patricia J.;Mooney, Marc E.;Hatsukami, Dorothy K.
虽然尼古丁戒断（NW）症状和渴望（NC）的性别差异已被广泛描述在成年吸烟者，很少有研究调查这些现象在青少年。我们调查了性别和激素避孕（HC）对NW和NC的影响，在青少年吸烟者戒烟的前14天内，使用来自经皮尼古丁替代疗法戒烟的随机、安慰剂对照、双盲试验的数据分析显示，无论HC的使用，男性和女性的NW严重程度相似。然而，在雌性动物中观察到的NC显著高于雄性动物（2.22 +/- 0.12 vs. 1.65 +/- 1.14; p = 0.003）。进一步.未使用HC的女性报告的NC水平最高（2.38 +/- 0.16），其次是使用HC的女性（2.08 +/- 0.25）和男性（1.71 +/- 0.16; p = 0.007）。此外，使用激素避孕药可能会影响渴望的严重程度。解决青少年的这些不同症状可能有助于提高这一特殊吸烟人群的戒烟率。(C)2009爱思唯尔有限公司版权所有。
While sex differences in the nicotine withdrawal (NW) symptoms and craving (NC) have been extensively described in adult cigarette smokers, few studies have investigated these phenomena in adolescents. We investigated the effect of gender and hormonal contraception (HC) on NW and NC during the first 14 days of cessation in adolescent smokers using data from a randomized, placebo-controlled, double-blind trial of the transdermal nicotine replacement therapy for smoking cessation.Analyses showed similar levels of NW severity in males and females, regardless of HC use. However, significantly higher NC was observed in females compared to males, (2.22 +/- 0.12 vs. 1.65 +/- 1.14; p = 0.003). Further. females not using HC reported the highest level of NC (2.38 +/- 0.16) followed by females using HC (2.08 +/- 0.25) and males (1.71 +/- 0.16; p = 0.007).The current findings suggest that adolescent females experience similar NW severity to males, but have stronger NC. Further, the use of hormonal contraceptives may impact the severity of craving. Addressing these different symptoms in adolescents may be useful in increasing smoking cessation rates in this special population of smokers. (C) 2009 Elsevier Ltd. All rights reserved.