A comparative study of the hemolytic effect of polyenic antibiotics and of other cholesterol-binding agents.
A comparative study of the hemolytic effect of polyenic antibiotics and of other cholesterol-binding agents.
复制标题
多烯类抗生素和其他胆固醇结合剂溶血作用的比较研究。
DOI：
10.1016/0006-2952(79)90003-0
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发表时间：
1979
影响因子：
5.8
通讯作者：
A. Bozzi
中科院分区：
文献类型：
--
作者：
R. Strom;C. Crifó;A. Bozzi
根据溶血效率对大环多烯抗生素进行了比较在所有情况下，除了较大的多烯抗生素外，（阿替霉素B和制霉菌素），实验结果与膜中存在大量彼此独立的相同结合位点相一致。不同的试剂产生协同或拮抗作用，表明毛地黄皂苷、链球菌溶血素O和菲律宾肽彼此之间以及与含菌胺的多烯之间具有不同的作用机制。
Macrocyclic polyenic antibiotics were compared, on the basis of their hemolytic efficiency (expressed as critical occupancy level and as mean intrinsic association constant) with each other and with other cholesterol-specific hemolytic agents, such as digitonin and streptolysin O.In all cases, except for the larger polyenic antibiotics (amphotericin B and nystatin), the experimental results were compatible with the existence in the membrane of a large number of identical binding sites which are independent from each other.Simultaneous addition of two different agents gave either synergistic or antagonistic effects, indicating that digitonin, streptolysin O and filipin have different mechanisms of action from each other and from the mycosamine-containing polyenes.