Intracerebroventricular injection of apelin-13 reduces food intake in the rat
Intracerebroventricular injection of apelin-13 reduces food intake in the rat
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DOI：
10.1016/s0304-3940(03)00351-3
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发表时间：
2003-12-15
影响因子：
2.5
通讯作者：
Dickson, SL
中科院分区：
文献类型：
--
作者：
Sunter, D;Hewson, AK;Dickson, SL
爱帕琳肽是一种最近被鉴定为APJ受体配体的肽，APJ受体是一种位于小肠和下丘脑等组织中的受体。已在脂肪组织、胃肠道、心脏和胃中检测到Apelin。最近的报道表明爱帕琳在血压调节和体液稳态控制中的作用。本研究检查了Wistar大鼠静脉内（IV）和脑室内（ICV）注射爱帕琳肽-13对食物摄入的影响。IV注射10 nmol爱帕琳-13在进食或禁食24小时的大鼠中均未引起食物摄入量的任何变化。ICV注射1和3 nmol爱帕琳-13导致进食和禁食大鼠的食物摄入减少。进食大鼠中，最早的摄食量减少发生在注射后4 h。在禁食大鼠中，仅在注射后24小时摄食量减少。这些数据提供了apelin-13在控制食物摄入中可能作用的证据。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Apelin is a peptide recently identified as a ligand for the APJ receptor, a receptor located in tissues such as the small intestine and in the hypothalamus. Apelin has been detected in adipose tissue, gastrointestinal tract, heart and stomach. Recent reports suggest a role for apelin in the regulation of blood pressure and the control of body fluid homeostasis. The present studies examined the consequences on food intake of intravenous (IV) and intracerebroventricular (ICV) injection of apelin-13 in the Wistar rat. IV injection of 10 nmol of apelin-13 did not cause any change in food intake in either fed or 24-h fasted rats. ICV injection of 1 and 3 nmol of apelin-13 resulted in a reduction in food intake in both fed and fasted rats. The earliest reduction in food intake occurred at 4 h post-injection in fed rats. In fasted rats, food intake was reduced at 24-h post-injection only. These data provide evidence of a possible role for apelin-13 in the control of food intake. (C) 2003 Elsevier Ireland Ltd. All rights reserved.