Fear extinction memory performance in a sample of stable, euthymic patients with bipolar disorder
Fear extinction memory performance in a sample of stable, euthymic patients with bipolar disorder
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DOI：
10.1016/j.jad.2015.06.053
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发表时间：
2015-10-01
影响因子：
6.6
通讯作者：
Risbrough, Victoria B.
中科院分区：
文献类型：
--
作者：
Acheson, Dean T.;Eyler, Lisa T.;Risbrough, Victoria B.
目的：情感失调是双相情感障碍（BD）的核心特征。在BD患者中观察到情感调节的神经回路异常，特别是杏仁核和眶额皮质（OFC）的结构和功能异常。恐惧消退是一个自动的情感调节过程，依赖于BD中异常的神经回路。因此，恐惧消退可能是有用的，在探测自动影响调节缺陷BD。我们测试的假设，BD是与能力降低，以消除恐惧respons.Methods：我们研究了恐惧条件反射，灭绝和灭绝记忆回忆在一个样本中的稳定，euthymic参与者与BD（n =19）与健康的比较参与者（n=32）。有限数量的主题（BD：n=12;健康的比较：n=11）进行了结构NRI扫描检查皮质大小协会与灭绝recall.Results：健康的比较和BD参与者都成功地获得了恐惧反应，但BD参与者的反应更大的惊吓威胁和安全的线索。两组都表现出明显的消退。BD组表现出较好的上级消退回忆。灭绝回忆与各组的右喙中额叶皮质厚度相关，而右OK表面积仅与健康对照组的回忆相关。局限性：局限性包括使用一个稳定的，高度筛选的样品和相对较少的参与者可用于MRI analysis.Conclusions：增加恐惧反应可能与BD患者的“特质”中断类似，以前描述的焦虑症。这项任务可能是有用的探测自动影响调节过程中的BD，并了解治疗反应。由爱思唯尔公司出版
Objectives: Affective dysregulation is a core feature of bipolar disorder (BD). Abnormalities in neural circuits underlying affect regulation have been observed in BD, specifically in the structure and function of the amygdala and orbital frontal cortex (OFC). Fear extinction is an automatic affect regulatory process relying on neural circuits that are abnormal in BD. Thus, fear extinction might be useful in probing automatic affect regulation deficits in BD. We tested the hypothesis that BD is associated with reduced ability to extinguish fear responses.Methods: We examined fear conditioning, extinction, and extinction memory recall in a sample of stable, euthymic participants with BD (n =19) vs healthy comparison participants (n=32). A limited number of subjects (BD: n=12; healthy comparison: n=11) underwent structural NRI scanning to examine cortical size associations with extinction recall.Results: Both healthy comparison and BD participants were successful in acquiring a fear response, but BD participants responded with greater startle to both threat and safety cues. Both groups showed significant extinction. The BD group showed superior extinction recall. Extinction recall was associated with right rostral middle frontal cortex thickness across groups, whereas right OK surface area was associated with recall only in healthy comparisons. Limitations: Limitations include use of a stable, highly screened sample and a relatively small number of participants available for MRI analysis.Conclusions: Increased fear reactivity may be related to a "trait" disruption in BD patients similar to that previously described in anxiety disorders. This task may be useful for probing automatic affect regulatory processes in BD, and understanding treatment response. Published by Elsevier B.V.