Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice
Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice
复制标题
甲卡西酮可增加小鼠的视觉诱发神经元活动并提高感觉处理效率
DOI：
10.1007/s12264-022-00965-z
复制
发表时间：
2022-11-30
影响因子：
5.6
通讯作者：
Han，Yunyun
中科院分区：
文献类型：
--
作者：
Zhou，Jun;Deng，Wen;Han，Yunyun
甲卡西酮（MCAT）属于被称为合成卡西酮的设计药物，在世界范围内被滥用于娱乐目的。它有很强的刺激作用，包括增强欣快、感觉、警觉和同理心。然而，关于MCAT在体内如何调节神经元活性的研究却知之甚少。在这里，我们评估了MCAT对神经元活动的影响与一系列的功能方法。C-Fos免疫组化结果显示，MCAT可使感觉和运动皮质、纹状体和中脑运动核团的激活神经元数量增加6倍，在体单细胞记录和双光子钙离子成像显示，MCAT可使大部分神经元的峰电位活动增加。值得注意的是，MCAT诱导了强烈的去相关性的人口活动和增加的试验到试验的可靠性，特别是在自然的电影刺激。它通过增强单个神经元的编码能力来提高信息加工效率，提示精神活性兴奋剂增强知觉的皮层网络机制。
Methcathinone (MCAT) belongs to the designer drugs called synthetic cathinones, which are abused worldwide for recreational purposes. It has strong stimulant effects, including enhanced euphoria, sensation, alertness, and empathy. However, little is known about how MCAT modulates neuronal activityin vivo. Here, we evaluated the effect of MCAT on neuronal activity with a series of functional approaches. C-Fos immunostaining showed that MCAT increased the number of activated neurons by 6-fold, especially in sensory and motor cortices, striatum, and midbrain motor nuclei.In vivosingle-unit recording and two-photon Ca2+imaging revealed that a large proportion of neurons increased spiking activity upon MCAT administration. Notably, MCAT induced a strong de-correlation of population activity and increased trial-to-trial reliability, specifically during a natural movie stimulus. It improved the information-processing efficiency by enhancing the single-neuron coding capacity, suggesting a cortical network mechanism of the enhanced perception produced by psychoactive stimulants.