TNF-α (-308) Gene Polymorphism and Type 2 Diabetes Mellitus in Ethiopian Diabetes Patients
TNF-α (-308) Gene Polymorphism and Type 2 Diabetes Mellitus in Ethiopian Diabetes Patients
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DOI：
10.2147/dmso.s229987
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Berhane, Nega
中科院分区：
文献类型：
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作者：
Ayelign, Birhanu;Genetu, Meaza;Berhane, Nega
背景：2型糖尿病（T2 DM）是一种由胰岛素功能或功能不足引起的代谢紊乱。T2 DM的易感因素主要是遗传和环境。肿瘤坏死因子-α（TNF-α）等细胞因子的遗传多态性提示干扰胰岛素敏感性葡萄糖摄取并诱导胰岛素抵抗，最终可能导致T2 DM。在这项研究中，我们评估了肿瘤坏死因子-α（-308）G/A基因多态性的影响，其与发展的T2 DM在埃塞俄比亚population.Methods：一个机构为基础的横断面研究进行了研究对象与T2 DM和非糖尿病健康对照。提取DNA，采用扩增阻滞突变系统聚合酶链反应进行基因分型。用Logistic回归和Student t检验评估T2 DM患者TNF-α（-308）G/A基因多态性。p值
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder resulting from insulin insufficiency or function. Predisposing factors for T2DM are mainly genetic and environmental. Genetic polymorphism of cytokines like tumor necrosis factor-alpha (TNF-alpha) is suggestive of interference with insulin-sensitive glucose uptake and induces insulin resistance that ultimately could lead to T2DM. In this study, we assessed the effect of TNF-alpha (-308) G/A gene polymorphism and its association with the development of T2DM in an Ethiopian population.Methods: An institutional-based cross-sectional study was conducted on study subjects with T2DM and non-diabetic healthy controls. DNA was extracted and genotyping was carried out by using amplification refractory mutation system polymerase chain reaction. A genetic-polymorphism on TNF-alpha (-308) G/A with T2DM was evaluated by logistic regression and Student's t-test. A P-value