MONONUCLEAR PHAGOCYTES - TISSUE DISTRIBUTION AND FUNCTIONAL-HETEROGENEITY
MONONUCLEAR PHAGOCYTES - TISSUE DISTRIBUTION AND FUNCTIONAL-HETEROGENEITY
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DOI：
10.1016/0952-7915(88)90047-7
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发表时间：
1988-09-01
影响因子：
7
通讯作者：
CHUNG, LP
中科院分区：
文献类型：
--
作者：
GORDON, S;KESHAV, S;CHUNG, LP
构成单核吞噬细胞系统（MPS）的细胞在稳态条件下广泛分布于全身，并在损伤、感染和免疫刺激后招募数量增加。它们的性质取决于它们的功能状态以及与微环境中的细胞和细胞外分子的局部相互作用。最近的研究探索了巨噬细胞的细胞生物学和生化特性，并开始确定其活动与一系列疾病过程的相关性。这篇综述将概述一些背景工作，这些工作导致了对巨噬细胞在体内显示的各种特性的认识。作为这些研究的结果，我们扩大了MPS的观点，除了它们在宿主防御中的传统作用外，还包括生理稳态功能。我们将参考最近的出版物，说明组织中巨噬细胞的性质和功能，并引用适当的评论。本卷的其他章节涉及完整宿主内巨噬细胞异质性的各个方面。
The cells which comprise the mononuclear phagocyte system (MPS) are widely distributed throughout the body under steady-state conditions and are recruited in increased numbers following injury, infection and immune stimulation. Their properties vary a great deal depending on their fUnctional state and on local interactions with cells and extracellular molecules in their microenvironment. Recent studies have explored the cell biology and biochemical properties of macrophages and have begun to define the relevance of their activities to a range of disease processes. This review will outline some of the background work that has led to an appreciation of the diverse properties which macrophages display within the body. As a result of these studies we have broadened our view of the MPS to include physiologic homeostatic functions in addition to their traditional role in host defence. We shall refer to recent publications which illustrate the nature and functions of macrophages in tissues and cite appropriate reviews. Other chapters in this volume deal with aspects of macrophage heterogeneity within the intact host.