SCHIZORIZA Encodes a Nuclear Factor Regulating Asymmetry of Stem Cell Divisions in the Arabidopsis Root
SCHIZORIZA Encodes a Nuclear Factor Regulating Asymmetry of Stem Cell Divisions in the Arabidopsis Root
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DOI：
10.1016/j.cub.2010.01.018
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发表时间：
2010-03-09
期刊：
影响因子：
9.2
通讯作者：
Heidstra, Renze
中科院分区：
文献类型：
--
作者：
Ten Hove, Colette A.;Willemsen, Viola;Heidstra, Renze
细胞分裂产生大小、形状、身份和功能不同的子细胞是许多发育过程不可或缺的，包括命运规范、组织模式和自我更新。在动物和酵母中，对描述良好的不对称细胞分裂所需因子的扰动通常会产生相同命运的细胞。在这里，我们报道了SCHIZORIZA (SCZ)，一个与热休克转录因子同源的核因子，它控制着一组干细胞中产生不同根组织（根帽、表皮、皮层和内胚层）的细胞命运分离。功能丧失、表达和重建实验表明，SCZ主要在干细胞生态位的皮质表达域内起作用，发挥自主和非自主作用，以指定皮质身份并控制周围层细胞命运的分离。因此，SCZ定义了植物细胞不对称分裂的新途径。
Cell divisions generating daughter cells different in size, shape, identity, and function are indispensable for many developmental processes including fate specification, tissue patterning, and self-renewal. In animals and yeast, perturbations in factors required for well-described asymmetric cell divisions generally yield cells of equal fate. Here we report on SCHIZORIZA (SCZ), a single nuclear factor with homology to heat-shock transcription factors that controls the separation of cell fate in a set of stem cells generating different root tissues: root cap, epidermis, cortex, and endodermis. Loss-of-function, expression, and reconstitution experiments indicate that SCZ acts mainly from within its cortical expression domain in the stem cell niche, exerting both autonomous and nonautonomous effects to specify cortex identity and control the separation of cell fates in surrounding layers. Thus, SCZ defines a novel pathway for asymmetric cell division in plants.