Platelet membrane fluidity in Alzheimer's disease and major depression.
Platelet membrane fluidity in Alzheimer's disease and major depression.
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阿尔茨海默病和重度抑郁症中的血小板膜流动性。
DOI：
10.1176/ajp.144.7.860
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Keefe,N
中科院分区：
文献类型：
--
作者：
Zubenko,GS;Cohen,BM;Reynolds3rd,CF;Boller,F;Malinakova,I;Keefe,N
对51例阿尔茨海默型痴呆患者、24例非痴呆性抑郁症患者和50例神经健康患者（年龄均为45岁以上）在37℃下进行血小板膜流动性的双盲荧光研究。从荧光探针1,6 -二苯基- 1,3,5 -己三烯的稳态各向异性可以看出，痴呆组血小板膜碳氢化合物区域的流动性明显大于抑郁对照组和正常对照组。在痴呆组中，血小板膜流动性与痴呆的严重程度显著相关，但与病程或发病年龄无关。血小板膜流动性增高的痴呆患者发病更早，痴呆更严重，恶化更迅速。（PsycINFO数据库记录(c) 2016 APA，版权所有）
Conducted double-blind fluorescence studies of platelet membrane fluidity at 37 C for 51 patients with Alzheimer-type dementia, 24 nondemented depressed patients, and 50 neurologically healthy Ss (all aged 45+ yrs). The fluidity of the hydrocarbon region of platelet membranes from the demented group, as reflected by the steady-state anisotropy of the fluorescent probe 1, 6-diphenyl-1, 3, 5-hexatriene, was significantly greater than that for the depressed and normal control Ss. Within the demented group, platelet membrane fluidity was significantly correlated with severity of dementia but not with duration of illness or age at onset. Demented patients with increased platelet membrane fluidity had an earlier onset, were more severely demented, and deteriorated more rapidly.(PsycINFO Database Record (c) 2016 APA, all rights reserved)